2-{{3-[(3S,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidin-3-yl]-propyl}-[2-(4-methoxy-benzylsulfanyl)-ethyl]-amino}-N-[2-(4-methoxy-benzylsulfanyl)-ethyl]-acetamide

Base Information

Chemical Name:2-{{3-[(3S,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidin-3-yl]-propyl}-[2-(4-methoxy-benzylsulfanyl)-ethyl]-amino}-N-[2-(4-methoxy-benzylsulfanyl)-ethyl]-acetamide
CAS No.:256375-14-1
Molecular Formula:C₃₇H₅₀ClN₃O₃S₂
Molecular Weight:684.407
Hs Code.:

2-{{3-[(3S,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidin-3-yl]-propyl}-[2-(4-methoxy-benzylsulfanyl)-ethyl]-amino}-N-[2-(4-methoxy-benzylsulfanyl)-ethyl]-acetamide

Synonyms:2-{{3-[(3S,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidin-3-yl]-propyl}-[2-(4-methoxy-benzylsulfanyl)-ethyl]-amino}-N-[2-(4-methoxy-benzylsulfanyl)-ethyl]-acetamide

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Chemical Property of 2-{{3-[(3S,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidin-3-yl]-propyl}-[2-(4-methoxy-benzylsulfanyl)-ethyl]-amino}-N-[2-(4-methoxy-benzylsulfanyl)-ethyl]-acetamide

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Technology Process of 2-{{3-[(3S,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidin-3-yl]-propyl}-[2-(4-methoxy-benzylsulfanyl)-ethyl]-amino}-N-[2-(4-methoxy-benzylsulfanyl)-ethyl]-acetamide

There total 8 articles about 2-{{3-[(3S,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidin-3-yl]-propyl}-[2-(4-methoxy-benzylsulfanyl)-ethyl]-amino}-N-[2-(4-methoxy-benzylsulfanyl)-ethyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 2-Bromo-N-[2-(4-methoxy-benzylsulfanyl)-ethyl]-acetamide

: 256375-13-0
{3-[(3S,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidin-3-yl]-propyl}-[2-(4-methoxy-benzylsulfanyl)-ethyl]-amine

: 256375-14-1
2-{{3-[(3S,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidin-3-yl]-propyl}-[2-(4-methoxy-benzylsulfanyl)-ethyl]-amino}-N-[2-(4-methoxy-benzylsulfanyl)-ethyl]-acetamide

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1016/S0960-894X(99)00562-4

Reference yield:

: 214335-16-7,205805-13-6
(-)-Methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3β-carboxylate

: 256375-14-1
2-{{3-[(3S,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidin-3-yl]-propyl}-[2-(4-methoxy-benzylsulfanyl)-ethyl]-amino}-N-[2-(4-methoxy-benzylsulfanyl)-ethyl]-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / LiAlH₄ / tetrahydrofuran

2: (COCl)2; DMSO; Et₃N / CH₂Cl₂

3: toluene

4: 100 percent / Mg; MeOH

5: 100 percent / aq. 6 N HCl

6: 75 percent / Et₃N; EDCI; DMAP / CH₂Cl₂

7: 60 percent / BH₃*THF; aq. HCl / tetrahydrofuran

8: 44 percent / Et₃N / CH₂Cl₂

With hydrogenchloride; methanol; dmap; lithium aluminium tetrahydride; borane-THF; oxalyl dichloride; magnesium; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; toluene; 1: Reduction / 2: Oxidation / 3: Condensation / 4: Reduction / 5: Hydrolysis / 6: Condensation / 7: Reduction / 8: Alkylation;
DOI:10.1016/S0960-894X(99)00562-4

Reference yield:

: 214335-31-6
(3S,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carbaldehyde

: 256375-14-1
2-{{3-[(3S,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidin-3-yl]-propyl}-[2-(4-methoxy-benzylsulfanyl)-ethyl]-amino}-N-[2-(4-methoxy-benzylsulfanyl)-ethyl]-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: toluene

2: 100 percent / Mg; MeOH

3: 100 percent / aq. 6 N HCl

4: 75 percent / Et₃N; EDCI; DMAP / CH₂Cl₂

5: 60 percent / BH₃*THF; aq. HCl / tetrahydrofuran

6: 44 percent / Et₃N / CH₂Cl₂

With hydrogenchloride; methanol; dmap; borane-THF; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; toluene; 1: Condensation / 2: Reduction / 3: Hydrolysis / 4: Condensation / 5: Reduction / 6: Alkylation;
DOI:10.1016/S0960-894X(99)00562-4