Phentermine hydrochloride

Base Information

• Chemical Name: Phentermine hydrochloride
• CAS No.: 1197-21-3
• Molecular Formula: C10H15N^.HCl
• Molecular Weight: 185.697
• Hs Code.: 2921460000
• European Community (EC) Number: 214-821-9
• NSC Number: 44090
• UNII: 0K2I505OTV
• DSSTox Substance ID: DTXSID20152550
• Wikidata: Q19885635
• NCI Thesaurus Code: C29361
• RXCUI: 82078
• ChEMBL ID: CHEMBL1200912
• Mol file: 1197-21-3.mol

Synonyms:Adipex P;Adipex-P;AdipexP;Duromine;Hydrochloride, Phentermine;Ionamine;Phentermine;Phentermine Hydrochloride

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Phentermine hydrochloride

Chemical Property:

• Vapor Pressure: 0.243mmHg at 25°C
• Melting Point: 200-201℃
• Boiling Point: 206 °C at 760 mmHg
• Flash Point: 93.1 °C
• PSA: 26.02000
• LogP: 3.46870
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 185.0971272
• Heavy Atom Count: 12
• Complexity: 112

Purity/Quality:

Safty Information:

• Pictogram(s): T,Xi
• Hazard Codes: T,Xi
• Statements: 25
• Safety Statements: 22-26-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(CC1=CC=CC=C1)N.Cl
• Recent ClinicalTrials: Long-term Effectiveness of the Antiobesity Medication Phentermine
• Recent EU Clinical Trials: A Qsymia? CardiovascuLAr morbIdity and Mortality (AQCLAIM) Study in Subjects with Documented Cardiovascular Disease
• Uses: Controlled substance (stimulant). Anorexic. An Amphetamine derivative.
• Therapeutic Function: Antiobesity

Technology Process of Phentermine hydrochloride

There total 12 articles about Phentermine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-dimethyl-3-phenylpropanoic acid (5669-14-7) → phentermine hydrochloride (1197-21-3)

Guidance literature:

2,2-dimethyl-3-phenylpropanoic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; for 5h; Reflux; Cooling;

With hydrogenchloride; acetic acid; In water; at 20 ℃;

Reference yield:

N-Benzhydrylidene-N'-(1,1-dimethyl-2-phenyl-ethyl)-hydrazine → phentermine hydrochloride (1197-21-3)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; at 50 ℃; under 760 Torr; Yield given;

DOI:10.1039/c39860000176

Reference yield:

Phentermin (122-09-8) → phentermine hydrochloride (1197-21-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; diethyl ether;

upstream raw materials:

N-(2-methyl-1-phenylpropan-2-yl)acetamide

C₂₂H₂₄NOP

2-azido-2-methyl-3-phenylpropane

benzyl bromide

Downstream raw materials:

4-methyl-N-(2-methyl-1-phenylpropan-2-yl)benzenesulfonamide

N-(2-methyl-1-phenylpropan-2-yl)-1-phenylmethanimine

N,N'-bis(2-methyl-3-phenyl-2-propyl)diazene

6-chloro-N₄-(1,1-dimethyl-2-phenylethyl)-2,4-pyrimidinediamine

Refernces

• 1、 -. "CHEMICAL COMPOUNDS". Page/Page column 115. . Retrieved 2010/11/04.
• 2、 Koziara, Anna,Osowska-Pacewicka, Krystyna,Zawadzki, Stefan,Zwierzak, Andrzej. "A Simple, One-Pot Transformation of t-Alkyl Chlorides Into (t-Alkyl)amines". . p. 487 - 489. Retrieved 2007/10/02.