Technology Process of 3-(6-amino-5-(1-(2,5-difluorophenyl)ethoxy)pyridin-3-yl)-5,6,7,8-tetrahydro-1,6-naphthyridin-8-ol
There total 12 articles about 3-(6-amino-5-(1-(2,5-difluorophenyl)ethoxy)pyridin-3-yl)-5,6,7,8-tetrahydro-1,6-naphthyridin-8-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
ethyl acetate;
at 0 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
2: trifluoroacetic acid / methanol; chloroform / 20 °C
3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate / 1,2-dimethoxyethane; water / 2.5 h / 90 °C / Inert atmosphere
4: hydrogenchloride / ethyl acetate / 0 - 20 °C
With
hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
In
methanol; 1,2-dimethoxyethane; dichloromethane; chloroform; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C
2.2: 0 - 20 °C
3.1: hydrogenchloride; iron / 3 h / 100 °C
4.1: N-Bromosuccinimide / acetonitrile / 0.67 h / 0 °C
5.1: dmap / N,N-dimethyl-formamide / 24 h / 20 °C
6.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / dimethyl sulfoxide / 3 h / 80 °C / Inert atmosphere
7.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate / 1,2-dimethoxyethane; water / 2.5 h / 90 °C / Inert atmosphere
8.1: hydrogenchloride / ethyl acetate / 0 - 20 °C
With
hydrogenchloride; dmap; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; iron; sodium hydride; caesium carbonate;
In
tetrahydrofuran; 1,2-dimethoxyethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;
