tert-butyl (3-((3-((4-Chlorophenyl)carbamoyl)naphthalen-2-yl)oxy)propyl)carbamate

Base Information

• Chemical Name: tert-butyl (3-((3-((4-Chlorophenyl)carbamoyl)naphthalen-2-yl)oxy)propyl)carbamate
• CAS No.: 1224567-51-4
• Molecular Formula: C₂₅H₂₇ClN₂O₄
• Molecular Weight: 454.953
• Mol file: 1224567-51-4.mol

Synonyms:tert-butyl (3-((3-((4-Chlorophenyl)carbamoyl)naphthalen-2-yl)oxy)propyl)carbamate

Chemical Property of tert-butyl (3-((3-((4-Chlorophenyl)carbamoyl)naphthalen-2-yl)oxy)propyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (3-((3-((4-Chlorophenyl)carbamoyl)naphthalen-2-yl)oxy)propyl)carbamate

There total 1 articles about tert-butyl (3-((3-((4-Chlorophenyl)carbamoyl)naphthalen-2-yl)oxy)propyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-tert-butoxycarbonyl-3-aminopropanol (58885-58-8) + naphthol AS-E (92-78-4) → tert-butyl (3-((3-((4-Chlorophenyl)carbamoyl)naphthalen-2-yl)oxy)propyl)carbamate (1224567-51-4)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 55.0%

tert-butyl (3-((3-((4-Chlorophenyl)carbamoyl)naphthalen-2-yl)oxy)propyl)carbamate (1224567-51-4) → 3-(3-aminopropoxy)-N-(4-chlorophenyl)-2-naphthamide hydrochloride (1224567-34-3)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

tert-butyl (3-((3-((4-Chlorophenyl)carbamoyl)naphthalen-2-yl)oxy)propyl)carbamate (1224567-51-4) → tert-butyl (3-((3-((3-((3-((4-Chlorophenyl)carbamoyl)-naphthalen-2-yl)oxy)propyl)carbamoyl)naphthalen-2-yl)oxy)-propyl)carbamate

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / diethyl ether; chloroform; methanol / 20 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 20 °C

With hydrogenchloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; dichloromethane; chloroform;

DOI:10.1021/acs.jmedchem.5b00468

upstream raw materials:

N-tert-butoxycarbonyl-3-aminopropanol

naphthol AS-E

Downstream raw materials:

3-(3-aminopropoxy)-N-(4-chlorophenyl)-2-naphthamide hydrochloride