N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(4-(tert-butyl)phenoxy)phenyl)-1-methyl-1H-pyrazole-5-carboxamide

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Chemical Name:N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(4-(tert-butyl)phenoxy)phenyl)-1-methyl-1H-pyrazole-5-carboxamide
CAS No.:1609174-20-0
Molecular Formula:C₃₈H₅₀N₄O₄
Molecular Weight:626.839
Hs Code.:

Synonyms:N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(4-(tert-butyl)phenoxy)phenyl)-1-methyl-1H-pyrazole-5-carboxamide

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Chemical Property of N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(4-(tert-butyl)phenoxy)phenyl)-1-methyl-1H-pyrazole-5-carboxamide

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Technology Process of N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(4-(tert-butyl)phenoxy)phenyl)-1-methyl-1H-pyrazole-5-carboxamide

There total 12 articles about N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(4-(tert-butyl)phenoxy)phenyl)-1-methyl-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1609174-20-0
N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(4-(tert-butyl)phenoxy)phenyl)-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: With copper diacetate; triethylamine; In dichloromethane; at 20 ℃; for 24h; Molecular sieve;

Reference yield:

: C₂₁H₂₁ClN₂O₂

: 457060-96-7
2-butoxy-4-(3-(diethylamino)propoxy)aniline

: 1609174-20-0
N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(4-(tert-butyl)phenoxy)phenyl)-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.ejmech.2014.03.072

Reference yield:

: 123324-71-0
p-tert-butylphenylboronic acid

: 1609174-20-0
N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(4-(tert-butyl)phenoxy)phenyl)-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: copper diacetate; triethylamine / dichloromethane / 24 h / 20 °C / Molecular sieve

2: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 20 °C

3: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 0 °C

4: triethylamine / tetrahydrofuran; dichloromethane / 1 h / 20 °C

With oxalyl dichloride; lithium hydroxide monohydrate; copper diacetate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2014.03.072