Ethanone, 1-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-

Base Information

• Chemical Name: Ethanone, 1-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-
• CAS No.: 149683-53-4
• Molecular Formula: C14H22O2Si
• Molecular Weight: 250.413
• DSSTox Substance ID: DTXSID70446153
• Nikkaji Number: J1.052.565I
• Wikidata: Q82264741
• Mol file: 149683-53-4.mol

Synonyms:149683-53-4;Ethanone, 1-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-;1-[4-[tert-butyl(dimethyl)silyl]oxyphenyl]ethanone;1-(4-((tert-Butyldimethylsilyl)oxy)phenyl)ethanone;SCHEMBL936407;DTXSID70446153;GPJCOEQTQFSCML-UHFFFAOYSA-N;4'-tert-butyldimethylsilyloxyacetophenone;4'-(tert-Butyldimethylsiloxy)acetophenone;1-[4(tert-butyldimethylsilanyloxy)phenyl]ethanone;EN300-19205572;1-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-ethanone;1-{4-[(tert-butyldimethylsilyl)oxy]phenyl}ethan-1-one

Chemical Property of Ethanone, 1-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 250.138906475
• Heavy Atom Count: 17
• Complexity: 270

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)C1=CC=C(C=C1)O[Si](C)(C)C(C)(C)C

Technology Process of Ethanone, 1-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-

There total 11 articles about Ethanone, 1-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 4-Hydroxyacetophenone (99-93-4) → 4-(tert-butyldimethylsilyloxy)acetophenone (149683-53-4)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1021/jo034255h

Reference yield: 98.0%

1H-imidazole (288-32-4) + tert-butyldimethylsilyl chloride (18162-48-6) + 4-Hydroxyacetophenone (99-93-4) → 4-(tert-butyldimethylsilyloxy)acetophenone (149683-53-4)

Guidance literature:

In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.75h;

Reference yield: 97.0%

tert-butyl-dimethyl-[4-(2-methyl-[1,3]dithian-2-yl)-phenoxy]-silane → 4-(tert-butyldimethylsilyloxy)acetophenone (149683-53-4)

Guidance literature:

With iron(III)-acetylacetonate; dihydrogen peroxide; sodium iodide; In water; ethyl acetate; at 20 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2013.07.130

upstream raw materials:

t-butyldimethylsilyl-4-bromophenol

acetic anhydride

tert-butyldimethylsilyl chloride

4-Hydroxyacetophenone

Downstream raw materials:

4-Hydroxyacetophenone

4'-benzyloxy-acetophenone

[4'-(tert-butyldimethylsilyloxy)-acetophenono-1,1'-ethanedithiolato-Pt(PPh₃)2]

[4'-(tert-butyldimethylsilyloxy)-acetophenono-1,1'-ethenedithiolato-Pd(PPh₃)2]