ethyl (4S)-4-[(4R)-3-benzyl-4-(hydroxymethyl)-2-oxooxazolidin-4-yl]-4-hydroxybutanoate

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Chemical Name:ethyl (4S)-4-[(4R)-3-benzyl-4-(hydroxymethyl)-2-oxooxazolidin-4-yl]-4-hydroxybutanoate
CAS No.:1421940-30-8
Molecular Formula:C₁₇H₂₃NO₆
Molecular Weight:337.373
Hs Code.:

Synonyms:ethyl (4S)-4-[(4R)-3-benzyl-4-(hydroxymethyl)-2-oxooxazolidin-4-yl]-4-hydroxybutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (4S)-4-[(4R)-3-benzyl-4-(hydroxymethyl)-2-oxooxazolidin-4-yl]-4-hydroxybutanoate

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Technology Process of ethyl (4S)-4-[(4R)-3-benzyl-4-(hydroxymethyl)-2-oxooxazolidin-4-yl]-4-hydroxybutanoate

There total 6 articles about ethyl (4S)-4-[(4R)-3-benzyl-4-(hydroxymethyl)-2-oxooxazolidin-4-yl]-4-hydroxybutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1421940-51-3
C₁₇H₂₁NO₆

: 1421940-30-8
ethyl (4S)-4-[(4R)-3-benzyl-4-(hydroxymethyl)-2-oxooxazolidin-4-yl]-4-hydroxybutanoate

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 0 - 20 ℃; for 2.16667h; Inert atmosphere;
DOI:10.1016/j.tetasy.2012.12.003

Reference yield:

: 1421940-24-0
ethyl (4S,2E)-4-{(4R)-3-benzyl-4-[(1S)-2-(benzyloxy)-1-hydroxyethyl]-2-oxooxazolidin-4-yl}-4-hydroxybut-2-enoate

: 1421940-30-8
ethyl (4S)-4-[(4R)-3-benzyl-4-(hydroxymethyl)-2-oxooxazolidin-4-yl]-4-hydroxybutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; 5%-palladium/activated carbon / ethanol / 19 h / 20 °C / Inert atmosphere

2: sodium periodate / methanol; water / 1 h / 20 °C / Inert atmosphere

3: sodium tetrahydroborate / ethanol / 2.17 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; sodium periodate; 5%-palladium/activated carbon; hydrogen; In methanol; ethanol; water;
DOI:10.1016/j.tetasy.2012.12.003

Reference yield:

: 1430738-72-9
C₂₁H₂₃NO₆

: 1421940-30-8
ethyl (4S)-4-[(4R)-3-benzyl-4-(hydroxymethyl)-2-oxooxazolidin-4-yl]-4-hydroxybutanoate

Guidance literature:: Multi-step reaction with 4 steps

1: benzoic acid / water / 26.5 h / 20 °C / Inert atmosphere

2: hydrogen; 5%-palladium/activated carbon / ethanol / 19 h / 20 °C / Inert atmosphere

3: sodium periodate / methanol; water / 1 h / 20 °C / Inert atmosphere

4: sodium tetrahydroborate / ethanol / 2.17 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; sodium periodate; 5%-palladium/activated carbon; hydrogen; benzoic acid; In methanol; ethanol; water;
DOI:10.1016/j.tetasy.2012.12.003