(S)-methyl 2-(2-(4-chlorophenyl)acetyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

Base Information

Chemical Name:(S)-methyl 2-(2-(4-chlorophenyl)acetyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
CAS No.:1394169-70-0
Molecular Formula:C₂₁H₂₂ClNO₅
Molecular Weight:403.862
Hs Code.:

Synonyms:(S)-methyl 2-(2-(4-chlorophenyl)acetyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

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Chemical Property of (S)-methyl 2-(2-(4-chlorophenyl)acetyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

Chemical Property:

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Technology Process of (S)-methyl 2-(2-(4-chlorophenyl)acetyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

There total 2 articles about (S)-methyl 2-(2-(4-chlorophenyl)acetyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1878-66-6
4-chlorophenylacetic Acid

: 175673-28-6
methyl (S)‐6,7‐dimethoxy‐1,2,3,4‐tetrahydroisoquinoline‐3‐carboxylate

: 1394169-70-0
(S)-methyl 2-(2-(4-chlorophenyl)acetyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.06.032

Reference yield:

: 76824-86-7,88980-03-4,103733-66-0
(S)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

: 1394169-70-0
(S)-methyl 2-(2-(4-chlorophenyl)acetyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 4 h / 0 °C / Reflux

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

With dmap; thionyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/j.ejmech.2012.06.032

Reference yield: 75.0%

: 1394169-70-0
(S)-methyl 2-(2-(4-chlorophenyl)acetyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

: 1394170-04-7
C₂₀H₂₀ClNO₅

Guidance literature:: (S)-methyl 2-(2-(4-chlorophenyl)acetyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate; With lithium hydroxide monohydrate; In methanol; at 20 ℃; for 24h;

With hydrogenchloride; In methanol; water;
DOI:10.1016/j.ejmech.2012.06.032