(E)-methyl 3-(5-methyl-2-(2-(2,2,2-trifluoroacetamido)ethyl)phenyl)allyl carbonate

Base Information

Chemical Name:(E)-methyl 3-(5-methyl-2-(2-(2,2,2-trifluoroacetamido)ethyl)phenyl)allyl carbonate
CAS No.:1268372-70-8
Molecular Formula:C₁₆H₁₈F₃NO₄
Molecular Weight:345.318
Hs Code.:

Synonyms:(E)-methyl 3-(5-methyl-2-(2-(2,2,2-trifluoroacetamido)ethyl)phenyl)allyl carbonate

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Chemical Property of (E)-methyl 3-(5-methyl-2-(2-(2,2,2-trifluoroacetamido)ethyl)phenyl)allyl carbonate

Chemical Property:

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Technology Process of (E)-methyl 3-(5-methyl-2-(2-(2,2,2-trifluoroacetamido)ethyl)phenyl)allyl carbonate

There total 4 articles about (E)-methyl 3-(5-methyl-2-(2-(2,2,2-trifluoroacetamido)ethyl)phenyl)allyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1268372-66-2
(E)-2,2,2-trifluoro-N-(2-(3-hydroxyprop-1-enyl)-4-methylphenethyl)acetamide

: 79-22-1
methyl chloroformate

: 1268372-70-8
(E)-methyl 3-(5-methyl-2-(2-(2,2,2-trifluoroacetamido)ethyl)phenyl)allyl carbonate

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 1.08333h; Inert atmosphere;
DOI:10.1002/anie.201006039

Reference yield:

: 1268372-77-5
C₁₁H₁₁F₃INO

: 1268372-70-8
(E)-methyl 3-(5-methyl-2-(2-(2,2,2-trifluoroacetamido)ethyl)phenyl)allyl carbonate

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / N,N-dimethyl-formamide / 16 h / 70 °C / Inert atmosphere

2: pyridine / dichloromethane / 1.08 h / 0 - 20 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; lithium chloride; In dichloromethane; N,N-dimethyl-formamide; 1: Stille coupling;
DOI:10.1002/anie.201006039

Reference yield:

: 3261-62-9
2-(p-tolyl)ethylamine

: 1268372-70-8
(E)-methyl 3-(5-methyl-2-(2-(2,2,2-trifluoroacetamido)ethyl)phenyl)allyl carbonate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

2: [bis(pyridine)iodine]⁺ tetrafluoroborate / Inert atmosphere

3: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / N,N-dimethyl-formamide / 16 h / 70 °C / Inert atmosphere

4: pyridine / dichloromethane / 1.08 h / 0 - 20 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; [bis(pyridine)iodine]⁺ tetrafluoroborate; triethylamine; lithium chloride; In dichloromethane; N,N-dimethyl-formamide; 3: Stille coupling;
DOI:10.1002/anie.201006039