(E)-2,2,2-trifluoro-N-(2-(3-hydroxyprop-1-enyl)-4-methylphenethyl)acetamide

Base Information

Chemical Name:(E)-2,2,2-trifluoro-N-(2-(3-hydroxyprop-1-enyl)-4-methylphenethyl)acetamide
CAS No.:1268372-66-2
Molecular Formula:C₁₄H₁₆F₃NO₂
Molecular Weight:287.282
Hs Code.:

Synonyms:(E)-2,2,2-trifluoro-N-(2-(3-hydroxyprop-1-enyl)-4-methylphenethyl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-2,2,2-trifluoro-N-(2-(3-hydroxyprop-1-enyl)-4-methylphenethyl)acetamide

Chemical Property:

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Technology Process of (E)-2,2,2-trifluoro-N-(2-(3-hydroxyprop-1-enyl)-4-methylphenethyl)acetamide

There total 3 articles about (E)-2,2,2-trifluoro-N-(2-(3-hydroxyprop-1-enyl)-4-methylphenethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1268372-77-5
C₁₁H₁₁F₃INO

: 82994-41-0,81925-29-3,74141-12-1,74141-13-2
(E)-3-(tri-n-butylstannyl)-2-propen-1-ol

: 1268372-66-2
(E)-2,2,2-trifluoro-N-(2-(3-hydroxyprop-1-enyl)-4-methylphenethyl)acetamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; lithium chloride; In N,N-dimethyl-formamide; at 70 ℃; for 16h; Inert atmosphere;
DOI:10.1002/anie.201006039

Reference yield:

: 3261-62-9
2-(p-tolyl)ethylamine

: 1268372-66-2
(E)-2,2,2-trifluoro-N-(2-(3-hydroxyprop-1-enyl)-4-methylphenethyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

2: [bis(pyridine)iodine]⁺ tetrafluoroborate / Inert atmosphere

3: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / N,N-dimethyl-formamide / 16 h / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; [bis(pyridine)iodine]⁺ tetrafluoroborate; triethylamine; lithium chloride; In dichloromethane; N,N-dimethyl-formamide; 3: Stille coupling;
DOI:10.1002/anie.201006039

Reference yield:

: 2,2,2-Trifluoro-N-(2-p-tolyl-ethyl)-acetamide

: 1268372-66-2
(E)-2,2,2-trifluoro-N-(2-(3-hydroxyprop-1-enyl)-4-methylphenethyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: [bis(pyridine)iodine]⁺ tetrafluoroborate / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / N,N-dimethyl-formamide / 16 h / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; [bis(pyridine)iodine]⁺ tetrafluoroborate; lithium chloride; In N,N-dimethyl-formamide; 2: Stille coupling;
DOI:10.1002/anie.201006039