5,5-difluoro-1-(4-fluoro-benzoyl)-piperidine-3-carboxylic acid ethyl ester

Base Information

Chemical Name:5,5-difluoro-1-(4-fluoro-benzoyl)-piperidine-3-carboxylic acid ethyl ester
CAS No.:915230-07-8
Molecular Formula:C₁₅H₁₆F₃NO₃
Molecular Weight:315.292
Hs Code.:

Synonyms:5,5-difluoro-1-(4-fluoro-benzoyl)-piperidine-3-carboxylic acid ethyl ester

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Chemical Property of 5,5-difluoro-1-(4-fluoro-benzoyl)-piperidine-3-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 5,5-difluoro-1-(4-fluoro-benzoyl)-piperidine-3-carboxylic acid ethyl ester

There total 4 articles about 5,5-difluoro-1-(4-fluoro-benzoyl)-piperidine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 915230-06-7
1-(4-fluoro-benzoyl)-5-oxy-piperidine-3-carboxylic acid ethyl ester

: 915230-07-8
5,5-difluoro-1-(4-fluoro-benzoyl)-piperidine-3-carboxylic acid ethyl ester

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at -78 - 20 ℃;

Reference yield:

: 915230-04-5
5-hydroxy-piperidine-3-carboxylic acid ethyl ester

: 915230-07-8
5,5-difluoro-1-(4-fluoro-benzoyl)-piperidine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 72 h / 20 °C

2.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 3.25 h / -78 °C

2.2: 0.5 h / -78 °C

3.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C

With 1-hydroxy-7-aza-benzotriazole; oxalyl dichloride; diethylamino-sulfur trifluoride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; dimethyl sulfoxide;

Reference yield:

: 915230-05-6
1-(4-fluoro-benzoyl)-5-hydroxy-piperidine-3-carboxylic acid ethyl ester

: 915230-07-8
5,5-difluoro-1-(4-fluoro-benzoyl)-piperidine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 3.25 h / -78 °C

1.2: 0.5 h / -78 °C

2.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C

With oxalyl dichloride; diethylamino-sulfur trifluoride; In dichloromethane; dimethyl sulfoxide;