{3,3-difluoro-5-[3-(1H-pyrrol-2-yl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(4-fluoro-phenyl)-methanone

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Chemical Name:{3,3-difluoro-5-[3-(1H-pyrrol-2-yl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(4-fluoro-phenyl)-methanone
CAS No.:915229-32-2
Molecular Formula:C₁₈H₁₅F₃N₄O₂
Molecular Weight:376.338
Hs Code.:

Synonyms:{3,3-difluoro-5-[3-(1H-pyrrol-2-yl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(4-fluoro-phenyl)-methanone

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Chemical Property of {3,3-difluoro-5-[3-(1H-pyrrol-2-yl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(4-fluoro-phenyl)-methanone

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Technology Process of {3,3-difluoro-5-[3-(1H-pyrrol-2-yl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(4-fluoro-phenyl)-methanone

There total 7 articles about {3,3-difluoro-5-[3-(1H-pyrrol-2-yl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(4-fluoro-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 500024-85-1
N'-hydroxy-1H-pyrrole-2-carboximidamide

: 915230-08-9
5,5-difluoro-1-(4-fluoro-benzoyl)-piperidine-3-carboxylic acid

: 915229-32-2
{3,3-difluoro-5-[3-(1H-pyrrol-2-yl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(4-fluoro-phenyl)-methanone

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; at 20 ℃; for 72h;

Reference yield:

: 4513-94-4
1H-pyrrole-2-carbonitrile

: 915229-32-2
{3,3-difluoro-5-[3-(1H-pyrrol-2-yl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(4-fluoro-phenyl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine / ethanol; water / 2 h / 20 °C / Heating / reflux

2: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,4-dioxane / 72 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; hydroxylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; ethanol; water;

Reference yield:

: 915230-04-5
5-hydroxy-piperidine-3-carboxylic acid ethyl ester

: 915229-32-2
{3,3-difluoro-5-[3-(1H-pyrrol-2-yl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(4-fluoro-phenyl)-methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 72 h / 20 °C

2.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 3.25 h / -78 °C

2.2: 0.5 h / -78 °C

3.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C

4.1: sodium hydroxide; water / 1,4-dioxane / 3 h / 20 °C

5.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,4-dioxane / 72 h / 20 °C

With sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; oxalyl dichloride; diethylamino-sulfur trifluoride; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide;