5-((2-(((4-methoxyphenyl)diphenylmethyl)amino)ethyl)amino)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile

Base Information

Chemical Name:5-((2-(((4-methoxyphenyl)diphenylmethyl)amino)ethyl)amino)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile
CAS No.:1449785-58-3
Molecular Formula:C₃₁H₂₇N₃O₃
Molecular Weight:489.574
Hs Code.:

Synonyms:5-((2-(((4-methoxyphenyl)diphenylmethyl)amino)ethyl)amino)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile

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Chemical Property of 5-((2-(((4-methoxyphenyl)diphenylmethyl)amino)ethyl)amino)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile

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Technology Process of 5-((2-(((4-methoxyphenyl)diphenylmethyl)amino)ethyl)amino)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile

There total 10 articles about 5-((2-(((4-methoxyphenyl)diphenylmethyl)amino)ethyl)amino)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: C₁₁H₁₁N₃O₂*2C₂HF₃O₂

: 14470-28-1
mono-4-methoxytrityl chloride

: 1449785-58-3
5-((2-(((4-methoxyphenyl)diphenylmethyl)amino)ethyl)amino)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile

Guidance literature:: With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 25 ℃; for 1h;

Reference yield: 48.0%

: 5-((2-aminoethyl)amino)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile

: 14470-28-1
mono-4-methoxytrityl chloride

: 1449785-58-3
5-((2-(((4-methoxyphenyl)diphenylmethyl)amino)ethyl)amino)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2018.12.021

Reference yield:

: 57319-65-0
6-aminophthalide

: 1449785-58-3
5-((2-(((4-methoxyphenyl)diphenylmethyl)amino)ethyl)amino)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile

Guidance literature:: Multi-step reaction with 9 steps

1: pyridine / dichloromethane / 1 h / 0 - 25 °C

2: N-Bromosuccinimide / tetrachloromethane / 2 h / 85 °C / Irradiation

3: water / 5 h / Reflux

4: hydrogenchloride / water / 2 h / 0 °C

5: dicyclohexyl-carbodiimide / water / 8 h / 0 - 25 °C

6: zinc; acetic acid / water / 0.5 h / 25 °C

7: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 5 h / 25 °C

8: dichloromethane / 0.5 h / 0 - 25 °C

9: triethylamine / N,N-dimethyl-formamide; dichloromethane / 1 h / 0 - 25 °C

With pyridine; hydrogenchloride; N-Bromosuccinimide; water; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; dicyclohexyl-carbodiimide; zinc; In tetrachloromethane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;