(1S,2S)-2-ethoxycarbonylamino-1-(4-nitrophenyl)-1,3-propanediol

Base Information

• Chemical Name: (1S,2S)-2-ethoxycarbonylamino-1-(4-nitrophenyl)-1,3-propanediol
• CAS No.: 945007-27-2
• Molecular Formula: C₁₂H₁₆N₂O₆
• Molecular Weight: 284.269
• Mol file: 945007-27-2.mol

Synonyms:(1S,2S)-2-ethoxycarbonylamino-1-(4-nitrophenyl)-1,3-propanediol

Chemical Property of (1S,2S)-2-ethoxycarbonylamino-1-(4-nitrophenyl)-1,3-propanediol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S)-2-ethoxycarbonylamino-1-(4-nitrophenyl)-1,3-propanediol

There total 1 articles about (1S,2S)-2-ethoxycarbonylamino-1-(4-nitrophenyl)-1,3-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol (119-62-0,716-61-0,2792-51-0,2792-52-1,2964-48-9,3689-55-2,63526-31-8,71115-69-0,140694-64-0) + chloroformic acid ethyl ester (541-41-3) → (1S,2S)-2-ethoxycarbonylamino-1-(4-nitrophenyl)-1,3-propanediol (945007-27-2)

Guidance literature:

With sodium carbonate; In dichloromethane; cooling;

DOI:10.1007/s10593-007-0201-z

Reference yield: 68.0%

(1S,2S)-2-ethoxycarbonylamino-1-(4-nitrophenyl)-1,3-propanediol (945007-27-2) → (1'S,4S)-4-[hydroxy(4-nitrophenyl)methyl]-1,3-oxazolidin-2-one (945007-29-4) + (4S,5S)-4-hydroxymethyl-5-(4-nitrophenyl)-1,3-oxazolidin-2-one

Guidance literature:

With sodium carbonate; In methanol; water; for 67h;

DOI:10.1007/s10593-007-0201-z

Reference yield: 57.0%

(1S,2S)-2-ethoxycarbonylamino-1-(4-nitrophenyl)-1,3-propanediol (945007-27-2) + butyryl chloride (141-75-3) → (4S,5S)-4-butanoyloxymethyl-5-(4-nitrophenyl)oxazolidin-2-one + (1'S,4S)-4-[butanoyloxy(4-nitrophenyl)methyl]oxazolidin-2-one

Guidance literature:

(1S,2S)-2-ethoxycarbonylamino-1-(4-nitrophenyl)-1,3-propanediol; With potassium carbonate; In methanol; for 120h; pH=9.5;

butyryl chloride; With pyridine; In chloroform; at 20 ℃; Further stages.;

DOI:10.1007/s10593-006-0118-y

upstream raw materials:

(1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol

chloroformic acid ethyl ester

Downstream raw materials:

(1'S,4S)-4-[hydroxy(4-nitrophenyl)methyl]-1,3-oxazolidin-2-one

(4S,5S)-4-(dichloroacetoxy)methyl-5-(4-nitrophenyl)-1,3-oxazolidin-2-one

(4S,5S)-3-[(4-chlorophenyl)carbamoyl]-4-hydroxymethyl-5-(4-nitrophenyl)-1,3-oxazolidin-2-one

(4S,5S)-3-[(4-chlorophenyl)carbamoyl]-4-[(4-chlorophenyl)carbamoyloxymethyl]-5-(4-nitrophenyl)-1,3-oxazolidin-2-one