benzyl 6-oxopipecolate

Base Information

Chemical Name:benzyl 6-oxopipecolate
CAS No.:259225-90-6
Molecular Formula:C₁₃H₁₅NO₃
Molecular Weight:233.267
Hs Code.:

Synonyms:benzyl 6-oxopipecolate

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Chemical Property of benzyl 6-oxopipecolate

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Technology Process of benzyl 6-oxopipecolate

There total 2 articles about benzyl 6-oxopipecolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 100-39-0
benzyl bromide

: 34622-39-4
(2S)-6-oxopipecolic acid

: 259225-90-6
benzyl 6-oxopipecolate

Guidance literature:: (2S)-6-oxopipecolic acid; With potassium tert-butylate; In N,N-dimethyl-formamide; for 1h;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 144h;
DOI:10.1248/cpb.47.1525

Reference yield:

: 1118-90-7
L-homoglutamic acid

: 259225-90-6
benzyl 6-oxopipecolate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 94 percent / AcOH / 6 h / Heating

2.1: KOtBu / dimethylformamide / 1 h

2.2: 49 percent / dimethylformamide / 144 h / 20 °C

With potassium tert-butylate; acetic acid; In N,N-dimethyl-formamide; 1.1: Cyclization / 2.1: Metallation / 2.2: Esterification;
DOI:10.1248/cpb.47.1525

Reference yield: 74.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 259225-90-6
benzyl 6-oxopipecolate

: 259181-46-9
benzyl N-benzyloxycarbonyl-6-oxopipecolate

Guidance literature:: benzyl 6-oxopipecolate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.25h;

benzyl chloroformate; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1248/cpb.47.1525