tert-butyl ((1-(4-(((benzyloxy)carbonyl)amino)phenyl)cyclopropyl)methyl)(cyclopropyl)carbamate

Base Information

• Chemical Name: tert-butyl ((1-(4-(((benzyloxy)carbonyl)amino)phenyl)cyclopropyl)methyl)(cyclopropyl)carbamate
• CAS No.: 1308815-51-1
• Molecular Formula: C₂₆H₃₂N₂O₄
• Molecular Weight: 436.551
• Mol file: 1308815-51-1.mol

Synonyms:tert-butyl ((1-(4-(((benzyloxy)carbonyl)amino)phenyl)cyclopropyl)methyl)(cyclopropyl)carbamate

Chemical Property of tert-butyl ((1-(4-(((benzyloxy)carbonyl)amino)phenyl)cyclopropyl)methyl)(cyclopropyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl ((1-(4-(((benzyloxy)carbonyl)amino)phenyl)cyclopropyl)methyl)(cyclopropyl)carbamate

There total 6 articles about tert-butyl ((1-(4-(((benzyloxy)carbonyl)amino)phenyl)cyclopropyl)methyl)(cyclopropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyl ((1-(4-aminophenyl)cyclopropyl)methyl)(cyclopropyl)carbamate (1308815-49-7) + benzyl chloroformate (501-53-1,94274-21-2) → tert-butyl ((1-(4-(((benzyloxy)carbonyl)amino)phenyl)cyclopropyl)methyl)(cyclopropyl)carbamate (1308815-51-1)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 10 - 25 ℃;

Reference yield:

1-(4-nitrophenyl)cyclopropane-1-carboxylic acid (23348-99-4) → tert-butyl ((1-(4-(((benzyloxy)carbonyl)amino)phenyl)cyclopropyl)methyl)(cyclopropyl)carbamate (1308815-51-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: triethylamine; methyl chloroformate / tetrahydrofuran / 0 - 10 °C / Inert atmosphere

1.2: 1 h / 0 °C

2.1: triethylamine / dichloromethane / 1 h / 0 - 5 °C

3.1: sodium hydrogencarbonate / acetonitrile / 5 h / 20 - 70 °C

4.1: ethyl acetate / 4 h / 20 °C

5.1: ammonium formate / palladium on carbon / methanol / 1 h / 60 °C

6.1: potassium carbonate / tetrahydrofuran / 10 - 25 °C

With ammonium formate; sodium hydrogencarbonate; potassium carbonate; triethylamine; methyl chloroformate; palladium on carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

1-(4-nitrophenyl)-hydroxymethylcyclopropane (23349-00-0) → tert-butyl ((1-(4-(((benzyloxy)carbonyl)amino)phenyl)cyclopropyl)methyl)(cyclopropyl)carbamate (1308815-51-1)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 1 h / 0 - 5 °C

2: sodium hydrogencarbonate / acetonitrile / 5 h / 20 - 70 °C

3: ethyl acetate / 4 h / 20 °C

4: ammonium formate / palladium on carbon / methanol / 1 h / 60 °C

5: potassium carbonate / tetrahydrofuran / 10 - 25 °C

With ammonium formate; sodium hydrogencarbonate; potassium carbonate; triethylamine; palladium on carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetonitrile;

upstream raw materials:

tert-butyl ((1-(4-aminophenyl)cyclopropyl)methyl)(cyclopropyl)carbamate

benzyl chloroformate

1-(4-nitrophenyl)cyclopropane-1-carboxylic acid

1-(4-nitrophenyl)-hydroxymethylcyclopropane