tert-butyl ((1-(4-(((benzyloxy)carbonyl)amino)phenyl)cyclopropyl)methyl)(cyclopropyl)carbamate

Base Information

Chemical Name:tert-butyl ((1-(4-(((benzyloxy)carbonyl)amino)phenyl)cyclopropyl)methyl)(cyclopropyl)carbamate
CAS No.:1308815-51-1
Molecular Formula:C₂₆H₃₂N₂O₄
Molecular Weight:436.551
Hs Code.:

Synonyms:tert-butyl ((1-(4-(((benzyloxy)carbonyl)amino)phenyl)cyclopropyl)methyl)(cyclopropyl)carbamate

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Chemical Property of tert-butyl ((1-(4-(((benzyloxy)carbonyl)amino)phenyl)cyclopropyl)methyl)(cyclopropyl)carbamate

Chemical Property:

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Technology Process of tert-butyl ((1-(4-(((benzyloxy)carbonyl)amino)phenyl)cyclopropyl)methyl)(cyclopropyl)carbamate

There total 6 articles about tert-butyl ((1-(4-(((benzyloxy)carbonyl)amino)phenyl)cyclopropyl)methyl)(cyclopropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1308815-49-7
tert-butyl ((1-(4-aminophenyl)cyclopropyl)methyl)(cyclopropyl)carbamate

: 501-53-1,94274-21-2
benzyl chloroformate

: 1308815-51-1
tert-butyl ((1-(4-(((benzyloxy)carbonyl)amino)phenyl)cyclopropyl)methyl)(cyclopropyl)carbamate

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 10 - 25 ℃;

Reference yield:

: 23348-99-4
1-(4-nitrophenyl)cyclopropane-1-carboxylic acid

: 1308815-51-1
tert-butyl ((1-(4-(((benzyloxy)carbonyl)amino)phenyl)cyclopropyl)methyl)(cyclopropyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; methyl chloroformate / tetrahydrofuran / 0 - 10 °C / Inert atmosphere

1.2: 1 h / 0 °C

2.1: triethylamine / dichloromethane / 1 h / 0 - 5 °C

3.1: sodium hydrogencarbonate / acetonitrile / 5 h / 20 - 70 °C

4.1: ethyl acetate / 4 h / 20 °C

5.1: ammonium formate / palladium on carbon / methanol / 1 h / 60 °C

6.1: potassium carbonate / tetrahydrofuran / 10 - 25 °C

With ammonium formate; sodium hydrogencarbonate; potassium carbonate; triethylamine; methyl chloroformate; palladium on carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

: 23349-00-0
1-(4-nitrophenyl)-hydroxymethylcyclopropane

: 1308815-51-1
tert-butyl ((1-(4-(((benzyloxy)carbonyl)amino)phenyl)cyclopropyl)methyl)(cyclopropyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 1 h / 0 - 5 °C

2: sodium hydrogencarbonate / acetonitrile / 5 h / 20 - 70 °C

3: ethyl acetate / 4 h / 20 °C

4: ammonium formate / palladium on carbon / methanol / 1 h / 60 °C

5: potassium carbonate / tetrahydrofuran / 10 - 25 °C

With ammonium formate; sodium hydrogencarbonate; potassium carbonate; triethylamine; palladium on carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetonitrile;