6-((7-aminobenzo[d]oxazol-2-yl)thio)-N-(2,6-diisopropylphenyl)hexanamide

Base Information

• Chemical Name: 6-((7-aminobenzo[d]oxazol-2-yl)thio)-N-(2,6-diisopropylphenyl)hexanamide
• CAS No.: 213685-86-0
• Molecular Formula: C₂₅H₃₃N₃O₂S
• Molecular Weight: 439.622
• Mol file: 213685-86-0.mol

Synonyms:6-((7-aminobenzo[d]oxazol-2-yl)thio)-N-(2,6-diisopropylphenyl)hexanamide

Chemical Property of 6-((7-aminobenzo[d]oxazol-2-yl)thio)-N-(2,6-diisopropylphenyl)hexanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-((7-aminobenzo[d]oxazol-2-yl)thio)-N-(2,6-diisopropylphenyl)hexanamide

There total 11 articles about 6-((7-aminobenzo[d]oxazol-2-yl)thio)-N-(2,6-diisopropylphenyl)hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

t-butyl (2-((6-((N-2,6-diisopropylphenyl)amino)-6-oxohexyl)thio)benzo[d]oxazol-7-yl)carbamate (213685-85-9) → 6-((7-aminobenzo[d]oxazol-2-yl)thio)-N-(2,6-diisopropylphenyl)hexanamide (213685-86-0)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2018.06.024

Reference yield: 45.0%

→ 6-((7-aminobenzo[d]oxazol-2-yl)thio)-N-(2,6-diisopropylphenyl)hexanamide (213685-86-0)

Guidance literature:

Reference yield:

2-mercaptobenzo[d]oxazole-7-carboxylic acid → 6-((7-aminobenzo[d]oxazol-2-yl)thio)-N-(2,6-diisopropylphenyl)hexanamide (213685-86-0)

Guidance literature:

Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / 72 h / Reflux

2: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 2 h / 80 °C

3: lithium hydroxide / tetrahydrofuran; water; tert-butyl alcohol / 12 h / 20 °C

4: triethylamine; diphenyl phosphoryl azide / 1.5 h / Reflux

5: trifluoroacetic acid / 2 h / 20 °C

With 18-crown-6 ether; diphenyl phosphoryl azide; potassium carbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/j.bmc.2018.06.024

upstream raw materials:

3-aminosalicylic acid

2-sulfanyl-7-(methoxy)carbonyl-1,3-benzoxazole

methyl 2-((6-((2,6-diisopropylphenyl)amino)-6-oxohexyl)thio)benzo[d]oxazole-7-carboxylate

6-bromo-N-(2,6-diisopropylphenyl)hexanamide

Downstream raw materials:

N-(2,6-diisopropylphenyl)-6-((7-(N,N-dimethylamino)benzo[d]oxazol-2-yl)thio)hexanamide