Phosphoric acid (2R,3S,5R)-3-(diisopropylamino-methoxy-phosphanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyl ester methyl ester

Base Information

• Chemical Name: Phosphoric acid (2R,3S,5R)-3-(diisopropylamino-methoxy-phosphanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyl ester methyl ester
• CAS No.: 117824-88-1
• Molecular Formula: C₄₄H₆₂N₄O₁₀P₂
• Molecular Weight: 868.945

Synonyms:Phosphoric acid (2R,3S,5R)-3-(diisopropylamino-methoxy-phosphanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyl ester methyl ester

Chemical Property of Phosphoric acid (2R,3S,5R)-3-(diisopropylamino-methoxy-phosphanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyl ester methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid (2R,3S,5R)-3-(diisopropylamino-methoxy-phosphanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyl ester methyl ester

There total 7 articles about Phosphoric acid (2R,3S,5R)-3-(diisopropylamino-methoxy-phosphanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

bis(N,N-diisopropylamino)methoxyphosphine (92611-10-4) + Phosphoric acid (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyl ester methyl ester (117824-87-0) → Phosphoric acid (2R,3S,5R)-3-(diisopropylamino-methoxy-phosphanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyl ester methyl ester (117824-88-1)

Guidance literature:

With N,N-diisopropylamine tetrazolide; In dichloromethane; at 30 ℃; for 1h;

DOI:10.1248/cpb.36.1386

Reference yield:

6-amino-1-hexanol (4048-33-3) → Phosphoric acid (2R,3S,5R)-3-(diisopropylamino-methoxy-phosphanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyl ester methyl ester (117824-88-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / diisopropylethylamine / CH₂Cl₂ / 0.17 h / Ambient temperature

2: 1H-tetrazole, I₂

3: 79 percent / NaOH / methanol; pyridine; H₂O / 0.17 h / 0 °C

4: 89 percent / diisopropylamine hydrotetrazolide / CH₂Cl₂ / 1 h / 30 °C

With 1H-tetrazole; sodium hydroxide; N,N-diisopropylamine tetrazolide; iodine; N-ethyl-N,N-diisopropylamine; In pyridine; methanol; dichloromethane; water;

DOI:10.1248/cpb.36.1386

Reference yield:

3'-O-benzoylthymidine (17331-53-2) → Phosphoric acid (2R,3S,5R)-3-(diisopropylamino-methoxy-phosphanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyl ester methyl ester (117824-88-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / diisopropylamine hydrotetrazolide / CH₂Cl₂ / 1 h / 30 °C

2: 1H-tetrazole, I₂

3: 79 percent / NaOH / methanol; pyridine; H₂O / 0.17 h / 0 °C

4: 89 percent / diisopropylamine hydrotetrazolide / CH₂Cl₂ / 1 h / 30 °C

With 1H-tetrazole; sodium hydroxide; N,N-diisopropylamine tetrazolide; iodine; In pyridine; methanol; dichloromethane; water;

DOI:10.1248/cpb.36.1386

upstream raw materials:

bis(N,N-diisopropylamino)methoxyphosphine

Phosphoric acid (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyl ester methyl ester

6-amino-1-hexanol

3'-O-benzoylthymidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 117824-88-1 Phosphoric acid (2R,3S,5R)-3-(diisopropylamino-methoxy-phosphanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyl ester methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send