92611-10-4

Basic information

• Product Name: METHYL TETRAISOPROPYLPHOSPHORODIAMIDITE
• Synonyms: METHYL N,N,N',N'-TETRAISOPROPYLPHOSPHORODIAMIDITE;METHYL TETRAISOPROPYLPHOSPHORODIAMIDITE;methyl N,N,N',N'-tetraisopropyl-phosphordiamidite;Bis(N,N-diisopropylamino)methoxyphosphine;Bis(diisopropylamino)methoxyphosphine;Methyl N,N,N',N'-tetraisopropylphosphorodiamidite 97%
• CAS NO: 92611-10-4
• Molecular Formula: C₁₃H₃₁N₂OP
• Molecular Weight: 276.4
• Product Categories: Catalysis and Inorganic Chemistry;Phosphorus Compounds;Phosphorus Precursors
• Mol File: 92611-10-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 74-75 °C0.45 mm Hg(lit.)
• Flash Point: 190 °F
• Appearance: /
• Density: 0.915 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.461(lit.)
• PKA: 7.49±0.70(Predicted)
• BRN: 4291461
• CAS DataBase Reference: METHYL TETRAISOPROPYLPHOSPHORODIAMIDITE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL TETRAISOPROPYLPHOSPHORODIAMIDITE(92611-10-4)
• EPA Substance Registry System: METHYL TETRAISOPROPYLPHOSPHORODIAMIDITE(92611-10-4)

Safety Data

• Hazard Codes: Xi
• Statements: 14-36/37/38
• Safety Statements: 7-26-36
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• F: 10
• Hazardous Substances Data: 92611-10-4(Hazardous Substances Data)

Usage

General Description

Methyl tetraisopropylphosphorodiamidite is a chemical compound commonly used as a reagent in the synthesis of oligonucleotides, which are short DNA or RNA molecules. It is widely used in the field of molecular biology and genetic engineering for the creation of custom DNA and RNA sequences. Methyl tetraisopropylphosphorodiamidite is a phosphoramidite derivative, containing a phosphorus atom bonded to four isopropyl groups, a methyl group, and a diamidite group. METHYL TETRAISOPROPYLPHOSPHORODIAMIDITE is known for its ability to efficiently and selectively add DNA or RNA building blocks during the synthesis of oligonucleotides, making it a key component in the production of custom DNA and RNA sequences for research and medical applications.

Upstream product

• 67-56-1 methanol 
• 56183-63-2 bis(diisopropylamino)chlorophosphine 
• 108-18-9 diisopropylamine 
• 3279-26-3 methyl dichlorophosphite 

Downstream Products

• 106022-56-4 Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester 
• 132469-08-0 Diisopropyl-phosphoramidous acid (2R,3S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-pent-4-enyl-tetrahydro-furan-3-yl ester methyl ester 
• 117854-36-1 Benzoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-(diisopropylamino-methoxy-phosphanyloxymethyl)-tetrahydro-furan-3-yl ester 
• 142068-19-7 Benzoic acid (2R,3S,5R)-3-(diisopropylamino-methoxy-phosphanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 660851-59-2 C₃₁H₄₀N₃O₂P 
• 904291-44-7 C₄₄H₆₄N₃O₁₁PSi₃ 
• 1005482-70-1 2'-O-(bis(2-acetoxyethoxy)methyl)-5'-O-[bis(trimethylsiloxy)(cyclododecyloxy)silyl]-4-N-(4,4'-dimethoxytrityl)-[3-15N,4-amino-15N]cytidine 3'-(N,N-diisopropyl)methoxyphosphoramidite 
• 1005482-72-3 C₁₀₄H₁₄₇N₃⁽¹⁵⁾N₄O₃₂P₂Si₃ 
• 1332728-76-3 N,N-diisopropyl methyl [1-(4-N-benzoylcytosin-1-yl)-2-O-benzoyloxymethoxymethyl-5-O-dimethoxytrityl-β-D-ribofuranos-3-O-yl]phosphoramidite 
• 1332728-70-7 N,N-diisopropyl methyl [1-(6-N-benzoyladenin-9-yl)-2-O-benzoyloxymethoxymethyl-5-O-dimethoxytrityl-β-D-ribofuranos-3-O-yl]phosphoramidite 
• 1332728-86-5 N,N-diisopropyl methyl [1-(6-N-benzoyladenine-9-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]phosphoramidite 
• 1332728-87-6 N,N-diisopropyl methyl [2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-1-(2-N-isobutyrylguanine-9-yl)-β-D-ribofuranos-5-O-yl]phosphoramidite 
• 1332728-89-8 N,N-diisopropyl methyl [2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-1-(uracil-1-yl)-β-D-ribofuranos-5-O-yl]phosphoramidite 
• 1332728-91-2 N,N-diisopropyl methyl [1-(4-N-benzoylcytosin-1-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]phosphoramidite 

Relevant articles and documents

Switching Lysophosphatidylserine G Protein-Coupled Receptor Agonists to Antagonists by Acylation of the Hydrophilic Serine Amine

Three human G protein-coupled receptors (GPCRs)—GPR34/LPS1, P2Y10/LPS2, and GPR174/LPS3—are activated specifically by lysophosphatidylserine (LysoPS), an endogenous hydrolysis product of a cell membrane component, phosphatidylserine (PS). LysoPS consists of-serine, glycerol, and fatty acid moieties connected by phosphodiester and ester linkages. We previously generated potent and selective GPCR agonists by modification of the three modules and the ester linkage. Here, we show that a novel modification of the hydrophilic serine moiety, that is, N-acylations of the serine amine, converted a GPR174 agonist to potent GPR174 antagonists. Structural exploration of the amide functionality provided access to a range of activities from agonist to partial agonist to antagonist. The present study would provide a new strategy for the development of lysophospholipid receptor antagonists.

CYCLIC NUCLEOTIDE ANALOGS

Disclosed herein are cyclic nucleotide analogs, methods of synthesizing cyclic nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with cyclic nucleotide analogs.

A chemical model for the enzymatic mono de-alkylation of (methyl and ethyl) parathion by glutathione-S-transferase

The NMR study of the reaction of methylparathion with thiol (glutathione) and a tertiary amine shows unambiguously a sequential transfer of the methyl group firstly to the amine and secondly to the thiol. The reaction stops after a single demethylation. This observation may account for regiospecificity of some glutathione S-transferases.