methyl 1-(but-2-yn-1-yl)-3,6-dimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

Chemical Name:methyl 1-(but-2-yn-1-yl)-3,6-dimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS No.:1315320-90-1
Molecular Formula:C₁₈H₂₀N₂O₃
Molecular Weight:312.368
Hs Code.:

Synonyms:methyl 1-(but-2-yn-1-yl)-3,6-dimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Chemical Property of methyl 1-(but-2-yn-1-yl)-3,6-dimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Technology Process of methyl 1-(but-2-yn-1-yl)-3,6-dimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 4 articles about methyl 1-(but-2-yn-1-yl)-3,6-dimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1315320-73-0
methyl 1-(but-2-yn-1-yl)-6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 74-88-4
methyl iodide

: 1315320-90-1
methyl 1-(but-2-yn-1-yl)-3,6-dimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ol2015658

Reference yield:

: 1315321-09-5
methyl 3-acetyl-1-(but-2-yn-1-yl)-6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 1315320-90-1
methyl 1-(but-2-yn-1-yl)-3,6-dimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 20 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With potassium carbonate; caesium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/ol2015658

Reference yield:

: 330567-73-2
methyl 3-acetyl-6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 1315320-90-1
methyl 1-(but-2-yn-1-yl)-3,6-dimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

2: potassium carbonate / methanol / 20 °C / Inert atmosphere

3: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; potassium carbonate; caesium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: Mitsunobu reaction;
DOI:10.1021/ol2015658