methyl 3-<6-acetoxy-1-(4-chlorobenzyl)-4-methyl-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

Base Information

Chemical Name:methyl 3-<6-acetoxy-1-(4-chlorobenzyl)-4-methyl-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate
CAS No.:150460-94-9
Molecular Formula:C₂₆H₂₈ClNO₄S
Molecular Weight:486.032
Hs Code.:

Synonyms:methyl 3-<6-acetoxy-1-(4-chlorobenzyl)-4-methyl-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

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Chemical Property of methyl 3-<6-acetoxy-1-(4-chlorobenzyl)-4-methyl-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

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Technology Process of methyl 3-<6-acetoxy-1-(4-chlorobenzyl)-4-methyl-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

There total 4 articles about methyl 3-<6-acetoxy-1-(4-chlorobenzyl)-4-methyl-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 144397-00-2
methyl 3-<1-(4-chlorobenzyl)-4-methyl-6-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

: 75-36-5
acetyl chloride

: 150460-94-9
methyl 3-<6-acetoxy-1-(4-chlorobenzyl)-4-methyl-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

Guidance literature:: With pyridine; In dichloromethane; for 0.5h; Ambient temperature;
DOI:10.1021/jm00071a008

Reference yield:

: 144396-98-5
methyl 3-<1-(4-chlorobenzyl)-3-(tert-butylthio)-5-(allyloxy)indol-2-yl>-2,2-dimethylpropanoate

: 150460-94-9
methyl 3-<6-acetoxy-1-(4-chlorobenzyl)-4-methyl-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) p-toluenesulfonic acid / 1.) 1,2-dichlorobenzene, reflux, 16 h, 2.) 1,2-dichlorobenzene, 150 deg C, 45 min

2: 81 percent / pyridine / CH₂Cl₂ / 0.5 h / Ambient temperature

With pyridine; toluene-4-sulfonic acid; In dichloromethane;
DOI:10.1021/jm00071a008

Reference yield:

: methyl 5-(t-butylthio)-2,2-dimethyl-4-oxopentanoate

: 150460-94-9
methyl 3-<6-acetoxy-1-(4-chlorobenzyl)-4-methyl-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 31 percent / NaOAc, glacial AcOH / toluene / 24 h

2: 2.) p-toluenesulfonic acid / 1.) 1,2-dichlorobenzene, reflux, 16 h, 2.) 1,2-dichlorobenzene, 150 deg C, 45 min

3: 81 percent / pyridine / CH₂Cl₂ / 0.5 h / Ambient temperature

With pyridine; sodium acetate; toluene-4-sulfonic acid; acetic acid; In dichloromethane; toluene;
DOI:10.1021/jm00071a008