3-[4-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indazol-1-yl]-propionic acid

Base Information

Chemical Name:3-[4-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indazol-1-yl]-propionic acid
CAS No.:1298129-68-6
Molecular Formula:C₂₄H₂₀F₂N₂O₄
Molecular Weight:438.431
Hs Code.:

Synonyms:3-[4-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indazol-1-yl]-propionic acid

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Chemical Property of 3-[4-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indazol-1-yl]-propionic acid

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Technology Process of 3-[4-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indazol-1-yl]-propionic acid

There total 9 articles about 3-[4-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indazol-1-yl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1298129-69-7
3-[4-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indazol-1-yl]-propionic acid ethyl ester

: 1298129-68-6
3-[4-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indazol-1-yl]-propionic acid

Guidance literature:: 3-[4-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indazol-1-yl]-propionic acid ethyl ester; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 3h;

With hydrogenchloride; In water; pH=3;

Reference yield:

: 83647-42-1
3-amino-2-methylbenzyl alcohol

: 1298129-68-6
3-[4-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indazol-1-yl]-propionic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium acetate; isopentyl nitrite / 18-crown-6 ether / chloroform

2.1: water; hydrogen bromide / Reflux

2.2: 5 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide; tetrahydrofuran / 70 °C

4.1: hydrogenchloride; water / methanol / 5 h / Reflux

4.2: pH 12 / Alkaline conditions

5.1: caesium carbonate / N,N-dimethyl-formamide / 20 - 90 °C

6.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C

6.2: pH 3

With hydrogenchloride; lithium hydroxide monohydrate; water; hydrogen bromide; potassium acetate; potassium carbonate; caesium carbonate; isopentyl nitrite; 18-crown-6 ether; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 870777-32-5
(4,5-difluoro-2-methoxyphenyl)boronic acid

: 1298129-68-6
3-[4-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indazol-1-yl]-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 80 - 85 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide; tetrahydrofuran / 70 °C

3.1: hydrogenchloride; water / methanol / 5 h / Reflux

3.2: pH 12 / Alkaline conditions

4.1: caesium carbonate / N,N-dimethyl-formamide / 20 - 90 °C

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C

5.2: pH 3

With hydrogenchloride; lithium hydroxide monohydrate; water; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;