Technology Process of 2-chloro-5-(2-methoxyethyl)benzoic acid
There total 3 articles about 2-chloro-5-(2-methoxyethyl)benzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
Pearlman's catalist;
In
ethyl acetate;
at 15 - 32 ℃;
for 18h;
under 3087.28 Torr;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere; Large scale reaction
1.2: 20 - 50 °C / Inert atmosphere; Large scale reaction
2.1: 10% Pd(OH)2/C; hydrogen / ethyl acetate / 18 h / 2327.23 Torr / Large scale reaction
With
10% Pd(OH)2/C; hydrogen; sodium hydride;
In
tetrahydrofuran; ethyl acetate; mineral oil;
DOI:10.1021/jo102070e
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / -30 - 20 °C / Inert atmosphere; Large scale reaction
1.2: 0 °C / Inert atmosphere; Large scale reaction
1.3: 10 - 20 °C / Large scale reaction
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere; Large scale reaction
2.2: 20 - 50 °C / Inert atmosphere; Large scale reaction
3.1: 10% Pd(OH)2/C; hydrogen / ethyl acetate / 18 h / 2327.23 Torr / Large scale reaction
With
10% Pd(OH)2/C; hydrogen; isopropylmagnesium chloride; sodium hydride;
In
tetrahydrofuran; ethyl acetate; mineral oil;
1.1: Bouveault aldehyde synthesis / 1.2: Bouveault aldehyde synthesis / 1.3: Bouveault aldehyde synthesis;
DOI:10.1021/jo102070e
