Technology Process of 2-chloro-N-cyclopropyl-5-(2-methoxyethyl)benzamide
There total 4 articles about 2-chloro-N-cyclopropyl-5-(2-methoxyethyl)benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-chloro-5-(2-methoxyethyl)benzoic acid;
With
1,1'-carbonyldiimidazole;
In
ethyl acetate;
at 10 - 20 ℃;
for 2h;
Cyclopropylamine;
In
ethyl acetate;
at 20 - 33.5 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere; Large scale reaction
1.2: 20 - 50 °C / Inert atmosphere; Large scale reaction
2.1: 10% Pd(OH)2/C; hydrogen / ethyl acetate / 18 h / 2327.23 Torr / Large scale reaction
3.1: 1,1'-carbonyldiimidazole / ethyl acetate / 2 h / 10 - 20 °C / Inert atmosphere; Large scale reaction
3.2: 30 °C / Inert atmosphere; Large scale reaction
With
10% Pd(OH)2/C; hydrogen; sodium hydride; 1,1'-carbonyldiimidazole;
In
tetrahydrofuran; ethyl acetate; mineral oil;
DOI:10.1021/jo102070e
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 10% Pd(OH)2/C; hydrogen / ethyl acetate / 18 h / 2327.23 Torr / Large scale reaction
2.1: 1,1'-carbonyldiimidazole / ethyl acetate / 2 h / 10 - 20 °C / Inert atmosphere; Large scale reaction
2.2: 30 °C / Inert atmosphere; Large scale reaction
With
10% Pd(OH)2/C; hydrogen; 1,1'-carbonyldiimidazole;
In
ethyl acetate;
DOI:10.1021/jo102070e
