5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-benzyl phosphotriester

Base Information

Chemical Name:5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-benzyl phosphotriester
CAS No.:166318-80-5
Molecular Formula:C₂₇H₃₁N₁₀O₁₀P
Molecular Weight:686.578
Hs Code.:

Synonyms:5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-benzyl phosphotriester

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Chemical Property of 5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-benzyl phosphotriester

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Technology Process of 5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-benzyl phosphotriester

There total 3 articles about 5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-benzyl phosphotriester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 30516-87-1,399024-19-2
3'-azido-2',3'-deoxythymidine

: 166318-80-5
5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-benzyl phosphotriester

Guidance literature:: Multi-step reaction with 5 steps

1: DIPEA / acetonitrile / 0.25 h / 0 °C

2: 1.) 1H-tetrazole, 2.) H₂O / 1.) CH₃CN, 0 deg C, 30 min, 2.) 25 deg C, 45 min

3: I₂, H₂O, pyridine / 0.25 h / 25 °C

5: 63 percent / acetonitrile / 8 h / 85 °C

With pyridine; 1H-tetrazole; water; iodine; N-ethyl-N,N-diisopropylamine; In acetonitrile;

Reference yield:

: 151029-28-6
5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl) H-phosphonate diester

: 166318-80-5
5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-benzyl phosphotriester

Guidance literature:: Multi-step reaction with 3 steps

1: I₂, H₂O, pyridine / 0.25 h / 25 °C

3: 63 percent / acetonitrile / 8 h / 85 °C

With pyridine; water; iodine; In acetonitrile;