C₂₅H₂₆FN₃O₃

Base Information

Chemical Name:C₂₅H₂₆FN₃O₃
CAS No.:1160359-89-6
Molecular Formula:C₂₅H₂₆FN₃O₃
Molecular Weight:435.498
Hs Code.:

C<sub>25</sub>H<sub>26</sub>FN<sub>3</sub>O<sub>3</sub>

Synonyms:C₂₅H₂₆FN₃O₃

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Chemical Property of C₂₅H₂₆FN₃O₃

Chemical Property:

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Technology Process of C₂₅H₂₆FN₃O₃

There total 6 articles about C₂₅H₂₆FN₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.6%

: 1160359-88-5
1-[1-(4-fluorophenyl)ethyl]-3-{hydroxy[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methyl}piperidin-2-one

: 1160359-89-6
C₂₅H₂₆FN₃O₃

Guidance literature:: 1-[1-(4-fluorophenyl)ethyl]-3-{hydroxy[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methyl}piperidin-2-one; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.833333h;

With triethylamine; In dichloromethane; at -78 - 20 ℃;

Reference yield:

: 403-40-7
1-(4-fluorophenyl)ethylamine

: 1160359-89-6
C₂₅H₂₆FN₃O₃

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 60 °C

3.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane / 1 h / -78 - -20 °C

3.2: 0.5 h / -78 °C

4.1: Dess-Martin periodane / dichloromethane / 3 h

With pyridine; sodium hydride; Dess-Martin periodane; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1119-46-6
5-chloro-valeric acid

: 1160359-89-6
C₂₅H₂₆FN₃O₃

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 60 °C

3.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane / 1 h / -78 - -20 °C

3.2: 0.5 h / -78 °C

4.1: Dess-Martin periodane / dichloromethane / 3 h

With sodium hydride; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; N,N-dimethyl-formamide; mineral oil;