(+/-)-(E)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid methyl ester

Base Information

Chemical Name:(+/-)-(E)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid methyl ester
CAS No.:129361-19-9
Molecular Formula:C₂₆H₂₆F₂N₂O₄
Molecular Weight:468.5
Hs Code.:

Synonyms:(+/-)-(E)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid methyl ester

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Chemical Property of (+/-)-(E)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid methyl ester

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Technology Process of (+/-)-(E)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid methyl ester

There total 4 articles about (+/-)-(E)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 129360-64-1
4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazole

: 129361-19-9
(+/-)-(E)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 6 h / Heating

2: 1.) NaH, 2.) n-butyllithium

With n-butyllithium; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jm00075a020

Reference yield:

: 129360-69-6
(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenol

: 129361-19-9
(+/-)-(E)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / MnO₂ / CH₂Cl₂ / 1 h / Ambient temperature

2: 1.) NaH, 2.) n-butyllithium

With manganese(IV) oxide; n-butyllithium; sodium hydride; In dichloromethane;
DOI:10.1021/jm00075a020

Reference yield:

: 129359-41-7
(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenoic acid, methyl ester

: 129361-19-9
(+/-)-(E)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / DIBAL-H / CH₂Cl₂ / 2 h / -78 °C

2: 75 percent / MnO₂ / CH₂Cl₂ / 1 h / Ambient temperature

3: 1.) NaH, 2.) n-butyllithium

With manganese(IV) oxide; n-butyllithium; sodium hydride; diisobutylaluminium hydride; In dichloromethane;
DOI:10.1021/jm00075a020