4-Benzo[1,3]dioxol-5-yl-2-[hydroxy-(3,4,5-trimethoxy-phenyl)-methyl]-4-oxo-butyric acid ethyl ester

Base Information

• Chemical Name: 4-Benzo[1,3]dioxol-5-yl-2-[hydroxy-(3,4,5-trimethoxy-phenyl)-methyl]-4-oxo-butyric acid ethyl ester
• CAS No.: 75404-01-2
• Molecular Formula: C₂₃H₂₆O₉
• Molecular Weight: 446.454
• Mol file: 75404-01-2.mol

Synonyms:4-Benzo[1,3]dioxol-5-yl-2-[hydroxy-(3,4,5-trimethoxy-phenyl)-methyl]-4-oxo-butyric acid ethyl ester

Chemical Property of 4-Benzo[1,3]dioxol-5-yl-2-[hydroxy-(3,4,5-trimethoxy-phenyl)-methyl]-4-oxo-butyric acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Benzo[1,3]dioxol-5-yl-2-[hydroxy-(3,4,5-trimethoxy-phenyl)-methyl]-4-oxo-butyric acid ethyl ester

There total 15 articles about 4-Benzo[1,3]dioxol-5-yl-2-[hydroxy-(3,4,5-trimethoxy-phenyl)-methyl]-4-oxo-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(2S,3S)-2-(Benzo[1,3]dioxole-5-carbonyl)-3-(3,4,5-trimethoxy-phenyl)-cyclopropanecarboxylic acid ethyl ester (75403-99-5,75443-63-9,76985-19-8) → 8-(3,4,5-Trimethoxy-phenyl)-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid ethyl ester + 4-Benzo[1,3]dioxol-5-yl-2-[hydroxy-(3,4,5-trimethoxy-phenyl)-methyl]-4-oxo-butyric acid ethyl ester (75404-01-2)

Guidance literature:

With tin(IV) chloride; In dichloromethane; for 72h; Ambient temperature;

Reference yield: 57.0%

ethyl 2-(3,4-methylenedioxybenzoyl)-3-(3,4,5-trimethoxyphenyl)-cyclopropanecarboxylate (75403-99-5,75443-63-9,76985-19-8) → 4-Benzo[1,3]dioxol-5-yl-5,6,7-trimethoxy-naphthalene-2-carboxylic acid ethyl ester (81649-62-9) + 4-Benzo[1,3]dioxol-5-yl-2-[hydroxy-(3,4,5-trimethoxy-phenyl)-methyl]-4-oxo-butyric acid ethyl ester (75404-01-2) + ethyl rel-(3R,4R)-6,7-methylenedioxy-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-3-carboxylate (75404-00-1,81649-61-8,106044-39-7,112026-11-6,114947-14-7)

Guidance literature:

With boron trifluoride diethyl etherate; In nitromethane; for 360h; Ambient temperature;

DOI:10.1039/P19820000271

Reference yield: 50.0%

ethyl 2-(3,4-methylenedioxybenzoyl)-3-(3,4,5-trimethoxyphenyl)-cyclopropanecarboxylate (76985-19-8) → (S)-4-Benzo[1,3]dioxol-5-yl-2-[(R)-hydroxy-(3,4,5-trimethoxy-phenyl)-methyl]-4-oxo-butyric acid ethyl ester (75404-01-2,76934-78-6,76934-79-7) + (R)-4-Benzo[1,3]dioxol-5-yl-2-[(R)-hydroxy-(3,4,5-trimethoxy-phenyl)-methyl]-4-oxo-butyric acid ethyl ester (75404-01-2,76934-78-6,76934-79-7) + ethyl rel-(3R,4R)-6,7-methylenedioxy-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-3-carboxylate (75404-00-1,81649-61-8,106044-39-7,112026-11-6,114947-14-7)

Guidance literature:

With tin(IV) chloride; In nitromethane; for 120h; Yields of byproduct given; Ambient temperature;

DOI:10.1016/S0040-4039(00)78730-2

upstream raw materials:

ethyl 2-(3,4-methylenedioxybenzoyl)-3-(3,4,5-trimethoxyphenyl)-cyclopropanecarboxylate

(2S,3S)-2-(Benzo[1,3]dioxole-5-carbonyl)-3-(3,4,5-trimethoxy-phenyl)-cyclopropanecarboxylic acid ethyl ester

5-Benzo[1,3]dioxol-5-yl-5-hydroxy-2-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan-3-carboxylic acid ethyl ester

ethyl 2-(3,4-methylenedioxybenzoyl)-3-(3,4,5-trimethoxyphenyl)-cyclopropanecarboxylate