76985-19-8

Upstream product

• 7380-81-6 ethyl (dimethylsulfuranylidene)acetate 
• 88775-47-7 (2E)-1-(2H-benzo[3,4-d]1,3-dioxolan-5-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 75403-98-4 3,4-methylenedioxy-3',4'-,5'-trimethoxy chalcone 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 81649-62-9 4-Benzo[1,3]dioxol-5-yl-5,6,7-trimethoxy-naphthalene-2-carboxylic acid ethyl ester 
• 75404-01-2 4-Benzo[1,3]dioxol-5-yl-2-[hydroxy-(3,4,5-trimethoxy-phenyl)-methyl]-4-oxo-butyric acid ethyl ester 
• 75404-00-1 ethyl rel-(3R,4R)-6,7-methylenedioxy-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-3-carboxylate 
• 75404-02-3 5-Benzo[1,3]dioxol-5-yl-5-hydroxy-2-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan-3-carboxylic acid ethyl ester 
• 106044-41-1 (5S,6R)-5-(3,4,5-Trimethoxy-phenyl)-5,6-dihydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid benzhydryl ester 
• 106044-41-1 (5S,6S)-5-(3,4,5-Trimethoxy-phenyl)-5,6-dihydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid benzhydryl ester 
• 477-47-4 (+/-) epipodophyllotoxin 
• 106044-46-6 (3aS,4R,5R,10bS)-3-Bromo-5-(3,4,5-trimethoxy-phenyl)-3a,4,5,10b-tetrahydro-1,7,9-trioxa-2-aza-dicyclopenta[a,g]naphthalene-4-carboxylic acid benzhydryl ester 
• 106044-47-7 (3aR,4S,5S,10bR)-3-Chloro-5-(3,4,5-trimethoxy-phenyl)-3a,4,5,10b-tetrahydro-1,7,9-trioxa-2-aza-dicyclopenta[a,g]naphthalene-4-carboxylic acid 
• 100146-47-2 (5R,6R)-8-Hydroxy-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid 
• 106044-42-2 (5R,6R)-5-(3,4,5-Trimethoxy-phenyl)-5,6-dihydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid 
• 75404-01-2 (S)-4-Benzo[1,3]dioxol-5-yl-2-[(R)-hydroxy-(3,4,5-trimethoxy-phenyl)-methyl]-4-oxo-butyric acid ethyl ester 
• 75404-01-2 (R)-4-Benzo[1,3]dioxol-5-yl-2-[(R)-hydroxy-(3,4,5-trimethoxy-phenyl)-methyl]-4-oxo-butyric acid ethyl ester 
• 108439-82-3 5-Benzo[1,3]dioxol-5-yl-5-oxo-3-(3,4,5-trimethoxy-phenyl)-pentanoic acid ethyl ester 

Relevant academic research and scientific papers

Tandem oxidation processes for the preparation of functionalized cyclopropanes

(Chemical Equation Presented) A novel manganese dioxide-mediated tandem oxidation process (TOP) has been developed which allows the direct conversion of allylic alcohols into cyclopropanes, the intermediate aldehydes being trapped in situ with a stabilized sulfur-ylide. This methodology has been applied successfully to a variety of allylic alcohols and to a formal synthesis of the simple, naturally occurring lignan, (±)-picropodophyllone.

An Improved Method for the Synthesis of Cyclopropyl Ketoesters

A simple and versatile method for the synthesis of cyclopropyl ketoesters starting from chalcones and ethyl cyanoacetate in benzene using sodium powder as base is described.

Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof

There is provided a novel and efficient stereoselective total synthesis of epipodophyllotoxin and related epipodophyllotoxin compounds of the general formula STR1 wherein R1 and R2 each are independently hydrogen or (lower)alkoxy, or R1 and R2, taken together, is methylenedioxy; R4 and R6 each are independently hydrogen or (lower)alkoxy; and R5 is hydrogen or a phenol-protecting group; or an acid addition salt thereof. The present invention also provides novel intermediates and processes for the preparation of said intermediates, which are then converted into known antineoplastic agents.