(1S)-1-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylthio}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one

Base Information

Chemical Name:(1S)-1-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylthio}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one
CAS No.:1215035-76-9
Molecular Formula:C₃₁H₄₃NO₂SSi
Molecular Weight:521.839
Hs Code.:

Synonyms:(1S)-1-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylthio}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one

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Chemical Property of (1S)-1-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylthio}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one

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Technology Process of (1S)-1-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylthio}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one

There total 4 articles about (1S)-1-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylthio}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1215035-82-7
C₃₆H₅₁NO₄SSi

: 1215035-76-9
(1S)-1-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylthio}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1002/ejoc.200901151

Reference yield:

: 1215035-73-6
C₃₃H₄₃NO₆SSi

: 1215035-76-9
(1S)-1-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylthio}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h

2.2: pH 9

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 194089-91-3
tert-butyl (2S,4R)-4-hydroxy-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)-pyrrolidine-1-carboxylate

: 1215035-76-9
(1S)-1-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylthio}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; triethylamine / 48 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 1 h

3.2: pH 9

With dmap; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;