(2R,2'S)-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]propyl phenyl sulfone

Base Information

Chemical Name:(2R,2'S)-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]propyl phenyl sulfone
CAS No.:233264-87-4
Molecular Formula:C₁₅H₂₄N₂O₃S
Molecular Weight:312.433
Hs Code.:

Synonyms:(2R,2'S)-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]propyl phenyl sulfone

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Chemical Property of (2R,2'S)-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]propyl phenyl sulfone

Chemical Property:

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Technology Process of (2R,2'S)-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]propyl phenyl sulfone

There total 1 articles about (2R,2'S)-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]propyl phenyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28691-72-7
(E)-1-propenyl phenyl sulfone

: 59983-39-0,187035-29-6
(S)-1-amino-2-(methoxymethyl)pyrrolidine

: 233264-87-4
(2R,2'S)-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]propyl phenyl sulfone

: (2S,2'S)-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]propyl phenyl sulfone

Guidance literature:: With ytterbium(III) triflate; In tetrahydrofuran; for 72h; Heating;
DOI:10.1002/(sici)1099-0690(200003)2000:6<879::aid-ejoc879>3.0.co;2-e

Reference yield:

: 233264-87-4
(2R,2'S)-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]propyl phenyl sulfone

: 155768-89-1
(R)-2-aminopropyl phenyl sulfone

Guidance literature:: With borane-THF; In tetrahydrofuran; for 5h; Heating;
DOI:10.1055/s-1999-972952

Reference yield:

: 233264-87-4
(2R,2'S)-2-[(2'-(methoxymethyl)pyrrolidin-1'-yl)amino]propyl phenyl sulfone

: 233264-92-1
(R)-2-dibenzylaminopropyl phenyl sulfone

Guidance literature:: Multi-step reaction with 2 steps

1: BH₃*THF / tetrahydrofuran / 5 h / Heating

2: 1.52 g / Na₂CO₃ / CH₂Cl₂; H₂O / Heating

With borane-THF; sodium carbonate; In tetrahydrofuran; dichloromethane; water; 1: Reduction / 2: Alkylation;
DOI:10.1002/(sici)1099-0690(200003)2000:6<879::aid-ejoc879>3.0.co;2-e