4-(chloroacetyl)-2-[4-(N,N-dimethylamino)phenyl]-5-(3,4,5-trimethoxyphenyl)-Δ2,3-oxadiazoline

Base Information

• Chemical Name: 4-(chloroacetyl)-2-[4-(N,N-dimethylamino)phenyl]-5-(3,4,5-trimethoxyphenyl)-Δ2,3-oxadiazoline
• CAS No.: 474398-60-2
• Molecular Formula: C₂₁H₂₄ClN₃O₅
• Molecular Weight: 433.892
• Mol file: 474398-60-2.mol

Synonyms:4-(chloroacetyl)-2-[4-(N,N-dimethylamino)phenyl]-5-(3,4,5-trimethoxyphenyl)-Δ2,3-oxadiazoline

Chemical Property of 4-(chloroacetyl)-2-[4-(N,N-dimethylamino)phenyl]-5-(3,4,5-trimethoxyphenyl)-Δ2,3-oxadiazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(chloroacetyl)-2-[4-(N,N-dimethylamino)phenyl]-5-(3,4,5-trimethoxyphenyl)-Δ2,3-oxadiazoline

There total 3 articles about 4-(chloroacetyl)-2-[4-(N,N-dimethylamino)phenyl]-5-(3,4,5-trimethoxyphenyl)-Δ2,3-oxadiazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

Chloroacetic anhydride (541-88-8) + 4-Dimethylamino-benzoic acid [1-(3,4,5-trimethoxy-phenyl)-meth-(E)-ylidene]-hydrazide → 4-(chloroacetyl)-2-[4-(N,N-dimethylamino)phenyl]-5-(3,4,5-trimethoxyphenyl)-Δ2,3-oxadiazoline (474398-60-2)

Guidance literature:

at 95 ℃; for 0.333333h;

DOI:10.1021/jm010231w

Reference yield:

4-(dimethylamino)benzohydrazide (19353-92-5) → 4-(chloroacetyl)-2-[4-(N,N-dimethylamino)phenyl]-5-(3,4,5-trimethoxyphenyl)-Δ2,3-oxadiazoline (474398-60-2)

Guidance literature:

Multi-step reaction with 2 steps

1: AcOH / ethanol / 0.33 h

2: 55 percent / 0.33 h / 95 °C

With acetic acid; In ethanol;

DOI:10.1021/jm010231w

Reference yield:

N-Boc-N'-[4-(N,N-dimethylamino)benzoyl]hydrazine (380922-13-4) → 4-(chloroacetyl)-2-[4-(N,N-dimethylamino)phenyl]-5-(3,4,5-trimethoxyphenyl)-Δ2,3-oxadiazoline (474398-60-2)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / CH₂Cl₂ / 2 h / 0 °C

2: AcOH / ethanol / 0.33 h

3: 55 percent / 0.33 h / 95 °C

With acetic acid; trifluoroacetic acid; In ethanol; dichloromethane;

DOI:10.1021/jm010231w

upstream raw materials:

Chloroacetic anhydride

4-(dimethylamino)benzohydrazide

N-Boc-N'-[4-(N,N-dimethylamino)benzoyl]hydrazine

Downstream raw materials:

2-amino-1-[5-(4-dimethylamino-phenyl)-2-(3,4,5-trimethoxy-phenyl)-[1,3,4]oxadiazol-3-yl]-ethanone

acetic acid 2-[5-(4-dimethylamino-phenyl)-2-(3,4,5-trimethoxy-phenyl)-[1,3,4]oxadiazol-3-yl]-2-oxo-ethyl ester

2-azido-1-[5-(4-dimethylamino-phenyl)-2-(3,4,5-trimethoxy-phenyl)-[1,3,4]oxadiazol-3-yl]-ethanone