2-azido-1-[5-(4-dimethylamino-phenyl)-2-(3,4,5-trimethoxy-phenyl)-[1,3,4]oxadiazol-3-yl]-ethanone

Base Information

Chemical Name:2-azido-1-[5-(4-dimethylamino-phenyl)-2-(3,4,5-trimethoxy-phenyl)-[1,3,4]oxadiazol-3-yl]-ethanone
CAS No.:380922-02-1
Molecular Formula:C₂₁H₂₄N₆O₅
Molecular Weight:440.459
Hs Code.:

Synonyms:2-azido-1-[5-(4-dimethylamino-phenyl)-2-(3,4,5-trimethoxy-phenyl)-[1,3,4]oxadiazol-3-yl]-ethanone

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Chemical Property of 2-azido-1-[5-(4-dimethylamino-phenyl)-2-(3,4,5-trimethoxy-phenyl)-[1,3,4]oxadiazol-3-yl]-ethanone

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Technology Process of 2-azido-1-[5-(4-dimethylamino-phenyl)-2-(3,4,5-trimethoxy-phenyl)-[1,3,4]oxadiazol-3-yl]-ethanone

There total 5 articles about 2-azido-1-[5-(4-dimethylamino-phenyl)-2-(3,4,5-trimethoxy-phenyl)-[1,3,4]oxadiazol-3-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 474398-60-2
4-(chloroacetyl)-2-[4-(N,N-dimethylamino)phenyl]-5-(3,4,5-trimethoxyphenyl)-Δ2,3-oxadiazoline

: 380922-02-1
2-azido-1-[5-(4-dimethylamino-phenyl)-2-(3,4,5-trimethoxy-phenyl)-[1,3,4]oxadiazol-3-yl]-ethanone

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 20 ℃; for 15h;
DOI:10.1021/jm010231w

Reference yield:

: 19353-92-5
4-(dimethylamino)benzohydrazide

: 380922-02-1
2-azido-1-[5-(4-dimethylamino-phenyl)-2-(3,4,5-trimethoxy-phenyl)-[1,3,4]oxadiazol-3-yl]-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: AcOH / ethanol / 0.33 h

2: 55 percent / 0.33 h / 95 °C

3: 100 percent / NaN₃ / dimethylformamide / 15 h / 20 °C

With sodium azide; acetic acid; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm010231w

Reference yield:

: 619-84-1
p-N,N-dimethylaminobenzoic acid

: 380922-02-1
2-azido-1-[5-(4-dimethylamino-phenyl)-2-(3,4,5-trimethoxy-phenyl)-[1,3,4]oxadiazol-3-yl]-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: EDCI; 4-(N,N-dimethylamino)pyridine / tetrahydrofuran; dimethylformamide / 17 h / 20 °C

2: trifluoroacetic acid / CH₂Cl₂ / 2 h / 0 °C

3: AcOH / ethanol / 0.33 h

4: 55 percent / 0.33 h / 95 °C

5: 100 percent / NaN₃ / dimethylformamide / 15 h / 20 °C

With dmap; sodium azide; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010231w