(Z)-2-(2,4-Dichloro-5-fluoro-benzoyl)-3-(4-methoxymethoxy-phenylamino)-acrylic acid methyl ester

Base Information

• Chemical Name: (Z)-2-(2,4-Dichloro-5-fluoro-benzoyl)-3-(4-methoxymethoxy-phenylamino)-acrylic acid methyl ester
• CAS No.: 767306-82-1
• Molecular Formula: C₁₉H₁₆Cl₂FNO₅
• Molecular Weight: 428.244

Synonyms:(Z)-2-(2,4-Dichloro-5-fluoro-benzoyl)-3-(4-methoxymethoxy-phenylamino)-acrylic acid methyl ester

Chemical Property of (Z)-2-(2,4-Dichloro-5-fluoro-benzoyl)-3-(4-methoxymethoxy-phenylamino)-acrylic acid methyl ester

Chemical Property:

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Technology Process of (Z)-2-(2,4-Dichloro-5-fluoro-benzoyl)-3-(4-methoxymethoxy-phenylamino)-acrylic acid methyl ester

There total 2 articles about (Z)-2-(2,4-Dichloro-5-fluoro-benzoyl)-3-(4-methoxymethoxy-phenylamino)-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2,4-dichloro-5-fluoro-benzoylacetate (103319-17-1) → (Z)-2-(2,4-Dichloro-5-fluoro-benzoyl)-3-(4-methoxymethoxy-phenylamino)-acrylic acid methyl ester (767306-82-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Ac₂O / 2 h / 130 °C

2: CH₂Cl₂ / 0.5 h / 20 °C

With acetic anhydride; In dichloromethane;

DOI:10.1021/jm0497895

Reference yield:

4-methoxymethyloxyaniline (876-30-2) + methyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-ethoxyacrylate (767306-81-0) → (Z)-2-(2,4-Dichloro-5-fluoro-benzoyl)-3-(4-methoxymethoxy-phenylamino)-acrylic acid methyl ester (767306-82-1)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/jm0497895

Reference yield:

(Z)-2-(2,4-Dichloro-5-fluoro-benzoyl)-3-(4-methoxymethoxy-phenylamino)-acrylic acid methyl ester (767306-82-1) → 7-chloro-6-fluoro-1-(4-methoxymethoxy-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methyl ester (402923-35-7)

Guidance literature:

With sodium hydride; In 1,2-dimethoxyethane; at 80 ℃; for 2h;

DOI:10.1021/jm0497895

upstream raw materials:

4-methoxymethyloxyaniline

methyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-ethoxyacrylate

methyl 2,4-dichloro-5-fluoro-benzoylacetate

Downstream raw materials:

7-chloro-6-fluoro-1-(4-methoxymethoxy-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methyl ester

7-chloro-6-fluoro-1-(4-methoxymethoxy-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

6-fluoro-1-(4-methoxymethoxy-phenyl)-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

6-fluoro-1-(4-hydroxy-phenyl)-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid benzyl ester

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