((2S,3R,4S)-4-amino-4-(2-fluorophenyl)-2-(trifluoromethyl)tetrahydrofuran-3-yl)methanol (2S,3S)-2,3-bis(benzoyloxy)succinic acid

Base Information

Chemical Name:((2S,3R,4S)-4-amino-4-(2-fluorophenyl)-2-(trifluoromethyl)tetrahydrofuran-3-yl)methanol (2S,3S)-2,3-bis(benzoyloxy)succinic acid
CAS No.:1388149-64-1
Molecular Formula:C₁₂H₁₃F₄NO₂*C₁₈H₁₄O₈
Molecular Weight:637.539
Hs Code.:

Synonyms:((2S,3R,4S)-4-amino-4-(2-fluorophenyl)-2-(trifluoromethyl)tetrahydrofuran-3-yl)methanol (2S,3S)-2,3-bis(benzoyloxy)succinic acid

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Chemical Property of ((2S,3R,4S)-4-amino-4-(2-fluorophenyl)-2-(trifluoromethyl)tetrahydrofuran-3-yl)methanol (2S,3S)-2,3-bis(benzoyloxy)succinic acid

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Technology Process of ((2S,3R,4S)-4-amino-4-(2-fluorophenyl)-2-(trifluoromethyl)tetrahydrofuran-3-yl)methanol (2S,3S)-2,3-bis(benzoyloxy)succinic acid

There total 7 articles about ((2S,3R,4S)-4-amino-4-(2-fluorophenyl)-2-(trifluoromethyl)tetrahydrofuran-3-yl)methanol (2S,3S)-2,3-bis(benzoyloxy)succinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17026-42-5
O,O'-dibenzoyl-D-tartaric acid

: ((2SR,3RS,4SR)-4-amino-4-(2-fluorophenyl)-2-(trifluoromethyl)tetrahydrofuran-3-yl)methanol

: 1388149-64-1
((2S,3R,4S)-4-amino-4-(2-fluorophenyl)-2-(trifluoromethyl)tetrahydrofuran-3-yl)methanol (2S,3S)-2,3-bis(benzoyloxy)succinic acid

Guidance literature:: In ethanol; water; at 67 ℃;

Reference yield:

: 1388149-60-7
1-(2-fluorophenyl)-2-((1,1,1-trifluorobut-3-en-2-yl)oxy)ethanone oxime

: 1388149-64-1
((2S,3R,4S)-4-amino-4-(2-fluorophenyl)-2-(trifluoromethyl)tetrahydrofuran-3-yl)methanol (2S,3S)-2,3-bis(benzoyloxy)succinic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroquinone / xylene / 18 h / 20 - 128 °C / Industry scale

2.1: zinc; acetic acid / water; tetrahydrofuran / 16 h / 10 - 20 °C

2.2: 30 °C

3.1: ethanol; water / 67 °C

With acetic acid; hydroquinone; zinc; In tetrahydrofuran; ethanol; water; xylene;

Reference yield:

: 1388149-61-8
1-(2-fluorophenyl)-2-((1,1,1-trifluorobut-3-en-2-yl)oxy)ethanone

: 1388149-64-1
((2S,3R,4S)-4-amino-4-(2-fluorophenyl)-2-(trifluoromethyl)tetrahydrofuran-3-yl)methanol (2S,3S)-2,3-bis(benzoyloxy)succinic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; sodium acetate / methanol / 2 h / 40 - 50 °C / Industry scale

2.1: hydroquinone / xylene / 18 h / 20 - 128 °C / Industry scale

3.1: zinc; acetic acid / water; tetrahydrofuran / 16 h / 10 - 20 °C

3.2: 30 °C

4.1: ethanol; water / 67 °C

With hydroxylamine hydrochloride; sodium acetate; acetic acid; hydroquinone; zinc; In tetrahydrofuran; methanol; ethanol; water; xylene;