N-(3-((4aS,5S,7aS)-2-amino-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(fluoromethyl)-pyrazine-2-carboxamide

Base Information

Chemical Name:N-(3-((4aS,5S,7aS)-2-amino-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(fluoromethyl)-pyrazine-2-carboxamide
CAS No.:1388149-44-7
Molecular Formula:C₁₉H₁₆F₅N₅O₂S
Molecular Weight:473.426
Hs Code.:

N-(3-((4aS,5S,7aS)-2-amino-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(fluoromethyl)-pyrazine-2-carboxamide

Synonyms:N-(3-((4aS,5S,7aS)-2-amino-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(fluoromethyl)-pyrazine-2-carboxamide

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Chemical Property of N-(3-((4aS,5S,7aS)-2-amino-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(fluoromethyl)-pyrazine-2-carboxamide

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Technology Process of N-(3-((4aS,5S,7aS)-2-amino-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(fluoromethyl)-pyrazine-2-carboxamide

There total 28 articles about N-(3-((4aS,5S,7aS)-2-amino-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(fluoromethyl)-pyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262803-66-6
5-(fluoromethyl)pyrazine-2-carboxylic acid

: 1388149-68-5
N-((4aS,5S,7aS)-7a-(5-amino-2-fluoro-phenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine

: 1388149-44-7
N-(3-((4aS,5S,7aS)-2-amino-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(fluoromethyl)-pyrazine-2-carboxamide

Guidance literature:: 5-(fluoromethyl)pyrazine-2-carboxylic acid; N-((4aS,5S,7aS)-7a-(5-amino-2-fluoro-phenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine; With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 20 - 45 ℃;

With ammonium hydroxide; In water; ethyl acetate;

Reference yield:

: 1388149-45-8
C₂₄H₂₄F₅N₅O₄S

: 1388149-44-7
N-(3-((4aS,5S,7aS)-2-amino-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(fluoromethyl)-pyrazine-2-carboxamide

Guidance literature:: C₂₄H₂₄F₅N₅O₄S; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 1262799-41-6
(3aR,4S,6aS)-6a-(2-fluorophenyl)-4-(trifluoromethyl)hexahydrofuro[3,4-c]isoxazole

: 1388149-44-7
N-(3-((4aS,5S,7aS)-2-amino-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(fluoromethyl)-pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: zinc; acetic acid / 0 - 20 °C

2.1: dichloromethane / 18 h / 20 °C

3.1: trifluoromethylsulfonic anhydride; pyridine / -20 - 0 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; methanol / 16 h / Reflux

5.1: nitric acid; trifluoroacetic acid; sulfuric acid / 0 - 20 °C

5.2: 5 - 21 °C

5.3: 35 - 40 °C

6.1: hydrogenchloride; ammonium chloride; iron / ethanol; water / 20 - 68 °C / Inert atmosphere

7.1: sodium hydroxide / water / 20 - 35 °C

8.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 20 - 45 °C

With pyridine; hydrogenchloride; methanol; trifluoromethylsulfonic anhydride; sulfuric acid; nitric acid; iron; ammonium chloride; acetic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; sodium hydroxide; zinc; In ethanol; dichloromethane; water; ethyl acetate;