potassium 3-{3-[4-(2-amino-benzoimidazol-1-yl)-3-hydroxy-butoxy]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoate

Base Information

Chemical Name:potassium 3-{3-[4-(2-amino-benzoimidazol-1-yl)-3-hydroxy-butoxy]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoate
CAS No.:1622069-40-2
Molecular Formula:C₂₃H₂₂N₅O₅*K
Molecular Weight:487.556
Hs Code.:

Synonyms:potassium 3-{3-[4-(2-amino-benzoimidazol-1-yl)-3-hydroxy-butoxy]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoate

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Chemical Property of potassium 3-{3-[4-(2-amino-benzoimidazol-1-yl)-3-hydroxy-butoxy]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoate

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Technology Process of potassium 3-{3-[4-(2-amino-benzoimidazol-1-yl)-3-hydroxy-butoxy]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoate

There total 4 articles about potassium 3-{3-[4-(2-amino-benzoimidazol-1-yl)-3-hydroxy-butoxy]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 934-32-7
1H-benzimidazol-2-amine

: 1622068-87-4
3-[3-(2-oxiranyl-ethoxy)-6-oxo-6H-pyridazin-1-ylmethyl]-benzoic acid methyl ester

: 1622069-40-2
potassium 3-{3-[4-(2-amino-benzoimidazol-1-yl)-3-hydroxy-butoxy]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoate

Guidance literature:: With potassium hydroxide; In methanol; water; at 100 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1129-28-8
3-methoxycarbonylbenzyl bromide

: 1622069-40-2
potassium 3-{3-[4-(2-amino-benzoimidazol-1-yl)-3-hydroxy-butoxy]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 20 °C

2: caesium carbonate; racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; palladium diacetate / toluene; acetonitrile / 10 h / 100 °C / Sealed tube; Inert atmosphere

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 14 h / 0 - 20 °C

4: potassium hydroxide / water; methanol / 1 h / 100 °C / Microwave irradiation

With racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; palladium diacetate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1621689-03-9
3-(3-chloro-6-oxo-6H-pyridazin-1-ylmethyl)-benzoic acid methyl ester

: 1622069-40-2
potassium 3-{3-[4-(2-amino-benzoimidazol-1-yl)-3-hydroxy-butoxy]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; palladium diacetate / toluene; acetonitrile / 10 h / 100 °C / Sealed tube; Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 14 h / 0 - 20 °C

3: potassium hydroxide / water; methanol / 1 h / 100 °C / Microwave irradiation

With racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; palladium diacetate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; In methanol; dichloromethane; water; toluene; acetonitrile;