1,8-diazabicyclo[5.4.0]undec-7-enium 5'-O-(4,4'-dimethoxytrityl)deoxycytidin-3'-yl phosphonate

Base Information

• Chemical Name: 1,8-diazabicyclo[5.4.0]undec-7-enium 5'-O-(4,4'-dimethoxytrityl)deoxycytidin-3'-yl phosphonate
• CAS No.: 145432-05-9
• Molecular Formula: C₉H₁₆N₂*C₃₀H₃₂N₃O₈P
• Molecular Weight: 745.813

Synonyms:1,8-diazabicyclo[5.4.0]undec-7-enium 5'-O-(4,4'-dimethoxytrityl)deoxycytidin-3'-yl phosphonate

Chemical Property of 1,8-diazabicyclo[5.4.0]undec-7-enium 5'-O-(4,4'-dimethoxytrityl)deoxycytidin-3'-yl phosphonate

Chemical Property:

Purity/Quality:

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Technology Process of 1,8-diazabicyclo[5.4.0]undec-7-enium 5'-O-(4,4'-dimethoxytrityl)deoxycytidin-3'-yl phosphonate

There total 4 articles about 1,8-diazabicyclo[5.4.0]undec-7-enium 5'-O-(4,4'-dimethoxytrityl)deoxycytidin-3'-yl phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-Deoxycytidine (951-77-9) → 1,8-diazabicyclo[5.4.0]undec-7-enium 5'-O-(4,4'-dimethoxytrityl)deoxycytidin-3'-yl phosphonate (145432-05-9)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / Ambient temperature

2: 61 percent / pyridine

With pyridine; In methanol;

DOI:10.1016/S0040-4039(00)61075-4

Reference yield:

N4-<(dimethylamino)methylene>-2'-deoxycytidine (17331-11-2) → 1,8-diazabicyclo[5.4.0]undec-7-enium 5'-O-(4,4'-dimethoxytrityl)deoxycytidin-3'-yl phosphonate (145432-05-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / pyridine

With pyridine;

DOI:10.1016/S0040-4039(00)61075-4

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 1,8-diazabicyclo[5.4.0]undec-7-enium 5'-O-(4,4'-dimethoxytrityl)deoxycytidin-3'-yl phosphonate (145432-05-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / pyridine

With pyridine;

DOI:10.1016/S0040-4039(00)61075-4

upstream raw materials:

N'-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-N,N-dimethyl-formamidine

N⁴-<(dimethylamino)methylene>-2'-deoxycytidine

4,4'-dimethoxytrityl chloride

2'-Deoxycytidine

Downstream raw materials:

O^5'-(4,4'-dimethoxy-trityl)-2'-deoxy-[3']cytidylic acid

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