(4-(benzyloxy)phenyl)chloroacetic acid ethyl ester

Base Information

• Chemical Name: (4-(benzyloxy)phenyl)chloroacetic acid ethyl ester
• CAS No.: 109394-53-8
• Molecular Formula: C₁₇H₁₇ClO₃
• Molecular Weight: 304.773
• Mol file: 109394-53-8.mol

Synonyms:(4-(benzyloxy)phenyl)chloroacetic acid ethyl ester

Chemical Property of (4-(benzyloxy)phenyl)chloroacetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-(benzyloxy)phenyl)chloroacetic acid ethyl ester

There total 6 articles about (4-(benzyloxy)phenyl)chloroacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(4-(benzyloxy)phenyl)hydroxyacetic acid ethyl ester (109089-89-6) → (4-(benzyloxy)phenyl)chloroacetic acid ethyl ester (109394-53-8)

Guidance literature:

With phosphorus pentachloride; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1021/jm9800402

Reference yield:

p-benzyloxybenzaldehyde (4397-53-9) → (4-(benzyloxy)phenyl)chloroacetic acid ethyl ester (109394-53-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / aq. NH₄Cl / diethyl ether / 24 h / 5 °C

2: 88 percent / HCl / diethyl ether / 24 h / 5 °C

3: 85 percent / PCl₅ / CH₂Cl₂ / 24 h / Ambient temperature

With hydrogenchloride; phosphorus pentachloride; ammonium chloride; In diethyl ether; dichloromethane;

DOI:10.1021/jm9800402

Reference yield:

α-Hydroxy-4-(phenylmethoxy)benzeneacetonitrile (58327-40-5,189683-89-4) → (4-(benzyloxy)phenyl)chloroacetic acid ethyl ester (109394-53-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / HCl / diethyl ether / 24 h / 5 °C

2: 85 percent / PCl₅ / CH₂Cl₂ / 24 h / Ambient temperature

With hydrogenchloride; phosphorus pentachloride; In diethyl ether; dichloromethane;

DOI:10.1021/jm9800402

upstream raw materials:

(4-(benzyloxy)phenyl)hydroxyacetic acid ethyl ester

p-benzyloxybenzaldehyde

α-Hydroxy-4-(phenylmethoxy)benzeneacetonitrile

p-hydroxymandelic acid ethyl ester

Downstream raw materials:

6-(benzyloxy)-2-(4-benzyloxyphenyl)benzofuran

Refernces