(R)-7-isopropyl-6-methyl-3-phenyl-2,3-dihydro-imidazo[5,1-b]oxazol-2-ium iodide

Base Information

Chemical Name:(R)-7-isopropyl-6-methyl-3-phenyl-2,3-dihydro-imidazo[5,1-b]oxazol-2-ium iodide
CAS No.:1220532-32-0
Molecular Formula:C₁₅H₁₉N₂O*I
Molecular Weight:370.233
Hs Code.:

Synonyms:(R)-7-isopropyl-6-methyl-3-phenyl-2,3-dihydro-imidazo[5,1-b]oxazol-2-ium iodide

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Chemical Property of (R)-7-isopropyl-6-methyl-3-phenyl-2,3-dihydro-imidazo[5,1-b]oxazol-2-ium iodide

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Technology Process of (R)-7-isopropyl-6-methyl-3-phenyl-2,3-dihydro-imidazo[5,1-b]oxazol-2-ium iodide

There total 5 articles about (R)-7-isopropyl-6-methyl-3-phenyl-2,3-dihydro-imidazo[5,1-b]oxazol-2-ium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1220532-26-2
(R)-7-isopropyl-3-phenyl-2,3-dihydro-imidazo[5,1-b]oxazole

: 74-88-4
methyl iodide

: 1220532-32-0
(R)-7-isopropyl-6-methyl-3-phenyl-2,3-dihydro-imidazo[5,1-b]oxazol-2-ium iodide

Guidance literature:: In acetonitrile; at 70 ℃; for 12h; Inert atmosphere; Sealed flask;
DOI:10.1021/ol1003737

Reference yield:

: 2-[N-formyl-1-amino-2-methylpropyl]-(R)-4-phenyloxazoline

: 1220532-32-0
(R)-7-isopropyl-6-methyl-3-phenyl-2,3-dihydro-imidazo[5,1-b]oxazol-2-ium iodide

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus pentoxide / toluene / 23 h / 100 °C / Schlenk technique; Inert atmosphere

2: acetonitrile / 12 h / 70 °C / Inert atmosphere; Sealed tube

With phosphorus pentoxide; In toluene; acetonitrile;

Reference yield:

: 4289-97-8
N-formyl-L-valine

: 1220532-32-0
(R)-7-isopropyl-6-methyl-3-phenyl-2,3-dihydro-imidazo[5,1-b]oxazol-2-ium iodide

Guidance literature:: Multi-step reaction with 4 steps

1.1: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 0.25 h / -15 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: dmap; p-toluenesulfonyl chloride; triethylamine / 1,2-dichloro-ethane / 4 h / 20 °C / Inert atmosphere; Reflux

3.1: phosphorus pentoxide / toluene / 23 h / 100 °C / Inert atmosphere; Schlenk technique

4.1: acetonitrile / 12 h / 70 °C / Inert atmosphere

With 4-methyl-morpholine; dmap; phosphorus pentoxide; triethylamine; p-toluenesulfonyl chloride; isobutyl chloroformate; In tetrahydrofuran; 1,2-dichloro-ethane; toluene; acetonitrile;