4-(4-{[3-(4-cyanobenzyl)-3H-imidazol-4-ylmethyl]amino}phenyl)-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Base Information

• Chemical Name: 4-(4-{[3-(4-cyanobenzyl)-3H-imidazol-4-ylmethyl]amino}phenyl)-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester
• CAS No.: 412332-16-2
• Molecular Formula: C₃₇H₃₄N₆O₂
• Molecular Weight: 594.716
• Mol file: 412332-16-2.mol

Synonyms:4-(4-{[3-(4-cyanobenzyl)-3H-imidazol-4-ylmethyl]amino}phenyl)-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Chemical Property of 4-(4-{[3-(4-cyanobenzyl)-3H-imidazol-4-ylmethyl]amino}phenyl)-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-{[3-(4-cyanobenzyl)-3H-imidazol-4-ylmethyl]amino}phenyl)-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

There total 1 articles about 4-(4-{[3-(4-cyanobenzyl)-3H-imidazol-4-ylmethyl]amino}phenyl)-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4-(4-aminophenyl)piperazine-1-N-9H-fluoren-9-ylmethyloxycarbonyl + 4-[(5-formyl-1H-imidazol-1-yl)methyl]benzonitrile (183500-37-0) → 4-(4-{[3-(4-cyanobenzyl)-3H-imidazol-4-ylmethyl]amino}phenyl)-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester (412332-16-2)

Guidance literature:

4-(4-aminophenyl)piperazine-1-N-9H-fluoren-9-ylmethyloxycarbonyl; 4-[(5-formyl-1H-imidazol-1-yl)methyl]benzonitrile; With acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 0.0833333h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane;

Reference yield: 45.0%

4-(4-{[3-(4-cyanobenzyl)-3H-imidazol-4-ylmethyl]amino}phenyl)-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester (412332-16-2) → C22H24N6 (412331-21-6)

Guidance literature:

With piperidine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.0833333h;

Reference yield:

4-(4-{[3-(4-cyanobenzyl)-3H-imidazol-4-ylmethyl]amino}phenyl)-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester (412332-16-2) + o-methylsulfanylphenylisocyanate (52260-30-7) → C30H31N7OS (412331-46-5)

Guidance literature:

4-(4-{[3-(4-cyanobenzyl)-3H-imidazol-4-ylmethyl]amino}phenyl)-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester; o-methylsulfanylphenylisocyanate; In toluene; at 60 ℃; for 1.5h;

With PS-trisamine resin; In toluene; at 20 ℃; for 4h;

upstream raw materials:

4-[(5-formyl-1H-imidazol-1-yl)methyl]benzonitrile

Downstream raw materials:

C₃₀H₃₁N₇OS

C₂₂H₂₄N₆

Refernces