[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]-N,N-bis(4-fluorophenyl)amine

Base Information

Chemical Name:[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]-N,N-bis(4-fluorophenyl)amine
CAS No.:409313-68-4
Molecular Formula:C₂₁H₂₇F₂N₃
Molecular Weight:359.462
Hs Code.:

Synonyms:[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]-N,N-bis(4-fluorophenyl)amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [3-(cis-3,5-dimethyl-1-piperazinyl)propyl]-N,N-bis(4-fluorophenyl)amine

Chemical Property:

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Technology Process of [3-(cis-3,5-dimethyl-1-piperazinyl)propyl]-N,N-bis(4-fluorophenyl)amine

There total 5 articles about [3-(cis-3,5-dimethyl-1-piperazinyl)propyl]-N,N-bis(4-fluorophenyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 3-(3,5-dimethyl-piperazin-1-yl)-N,N-bis-(4-fluoro-phenyl)-propionamide

: 409313-68-4
[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]-N,N-bis(4-fluorophenyl)amine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm030008u

Reference yield: 77.0%

: 409313-67-3
3-(3,5-dimethyl-piperazin-1-yl)-N,N-bis-(4-fluoro-phenyl)-propionamide

: 409313-68-4
[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]-N,N-bis(4-fluorophenyl)amine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;
DOI:10.1016/S0960-894X(01)00662-X

Reference yield:

: 330-91-6
bis-(4-fluoro-phenyl)-amine

: 409313-68-4
[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]-N,N-bis(4-fluorophenyl)amine

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / benzene / 5 h / Heating

2: 100 percent / aq. K₂CO₃ / dimethylformamide / 2 h / 80 °C

3: 77 percent / LAH / tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm030008u