1-((2R,6S)-4-{3-[Bis-(4-fluoro-phenyl)-amino]-propyl}-2,6-dimethyl-piperazin-1-yl)-3-phenyl-propan-1-one

Base Information

Chemical Name:1-((2R,6S)-4-{3-[Bis-(4-fluoro-phenyl)-amino]-propyl}-2,6-dimethyl-piperazin-1-yl)-3-phenyl-propan-1-one
CAS No.:409313-70-8
Molecular Formula:C₃₀H₃₅F₂N₃O
Molecular Weight:491.624
Hs Code.:

Synonyms:1-((2R,6S)-4-{3-[Bis-(4-fluoro-phenyl)-amino]-propyl}-2,6-dimethyl-piperazin-1-yl)-3-phenyl-propan-1-one

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Chemical Property of 1-((2R,6S)-4-{3-[Bis-(4-fluoro-phenyl)-amino]-propyl}-2,6-dimethyl-piperazin-1-yl)-3-phenyl-propan-1-one

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Technology Process of 1-((2R,6S)-4-{3-[Bis-(4-fluoro-phenyl)-amino]-propyl}-2,6-dimethyl-piperazin-1-yl)-3-phenyl-propan-1-one

There total 7 articles about 1-((2R,6S)-4-{3-[Bis-(4-fluoro-phenyl)-amino]-propyl}-2,6-dimethyl-piperazin-1-yl)-3-phenyl-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 645-45-4
hydrocinnamic acid chloride

: 409313-68-4
[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]-N,N-bis(4-fluorophenyl)amine

: 409313-70-8
1-((2R,6S)-4-{3-[Bis-(4-fluoro-phenyl)-amino]-propyl}-2,6-dimethyl-piperazin-1-yl)-3-phenyl-propan-1-one

Guidance literature:: In toluene; Heating;
DOI:10.1021/jm030008u

Reference yield:

: 330-91-6
bis-(4-fluoro-phenyl)-amine

: 409313-70-8
1-((2R,6S)-4-{3-[Bis-(4-fluoro-phenyl)-amino]-propyl}-2,6-dimethyl-piperazin-1-yl)-3-phenyl-propan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / benzene / 5 h / Heating

2: 100 percent / aq. K₂CO₃ / dimethylformamide / 2 h / 80 °C

3: 77 percent / LAH / tetrahydrofuran / 20 °C

4: 95 percent / toluene / Heating

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jm030008u

Reference yield:

: 3-(3,5-dimethyl-piperazin-1-yl)-N,N-bis-(4-fluoro-phenyl)-propionamide

: 409313-70-8
1-((2R,6S)-4-{3-[Bis-(4-fluoro-phenyl)-amino]-propyl}-2,6-dimethyl-piperazin-1-yl)-3-phenyl-propan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / LAH / tetrahydrofuran / 20 °C

2: 95 percent / toluene / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran; toluene;
DOI:10.1021/jm030008u