N-{2-[2-(2-cyano-ethyl)-5-(4-nitro-phenyl)-2H-pyrazol-3-ylamino]-phenyl}-2,2,2-trifluoro-acetamide

Base Information

• Chemical Name: N-{2-[2-(2-cyano-ethyl)-5-(4-nitro-phenyl)-2H-pyrazol-3-ylamino]-phenyl}-2,2,2-trifluoro-acetamide
• CAS No.: 910579-09-8
• Molecular Formula: C₂₀H₁₅F₃N₆O₃
• Molecular Weight: 444.373

Synonyms:N-{2-[2-(2-cyano-ethyl)-5-(4-nitro-phenyl)-2H-pyrazol-3-ylamino]-phenyl}-2,2,2-trifluoro-acetamide

Chemical Property of N-{2-[2-(2-cyano-ethyl)-5-(4-nitro-phenyl)-2H-pyrazol-3-ylamino]-phenyl}-2,2,2-trifluoro-acetamide

Chemical Property:

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Technology Process of N-{2-[2-(2-cyano-ethyl)-5-(4-nitro-phenyl)-2H-pyrazol-3-ylamino]-phenyl}-2,2,2-trifluoro-acetamide

There total 2 articles about N-{2-[2-(2-cyano-ethyl)-5-(4-nitro-phenyl)-2H-pyrazol-3-ylamino]-phenyl}-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(4-nitrophenacyl)-1H-benzimidazole cyanoethylhydrazone + trifluoroacetic anhydride (407-25-0) → N-{2-[2-(2-cyano-ethyl)-5-(4-nitro-phenyl)-2H-pyrazol-3-ylamino]-phenyl}-2,2,2-trifluoro-acetamide (910579-09-8)

Guidance literature:

In 1,4-dioxane;

DOI:10.1007/s10593-006-0012-7

Reference yield:

2-(1H-benzimidazol-2-yl)-1-(4-nitrophenyl)ethan-1-one (327091-99-6) → N-{2-[2-(2-cyano-ethyl)-5-(4-nitro-phenyl)-2H-pyrazol-3-ylamino]-phenyl}-2,2,2-trifluoro-acetamide (910579-09-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 37 percent / glac. acetic acid / dimethylsulfoxide / 5 h / 90 - 95 °C

2: 90 percent / dioxane

With acetic acid; In 1,4-dioxane; dimethyl sulfoxide;

DOI:10.1007/s10593-006-0012-7

Reference yield: 95.0%

N-{2-[2-(2-cyano-ethyl)-5-(4-nitro-phenyl)-2H-pyrazol-3-ylamino]-phenyl}-2,2,2-trifluoro-acetamide (910579-09-8) → 2-(4-nitro-phenyl)-4,5-dihydro-3,3a,6,10b-tetraaza-cyclopenta[c]fluorene

Guidance literature:

With hydrogenchloride; acetic acid; at 100 ℃; for 5h;

DOI:10.1007/s10593-006-0012-7

upstream raw materials:

trifluoroacetic anhydride

2-(1H-benzimidazol-2-yl)-1-(4-nitrophenyl)ethan-1-one

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