327091-99-6

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 615-15-6 2-Methyl-1H-benzimidazole 

Downstream Products

• 921438-96-2 C₂₄H₁₈N₄O₄ 
• 1042742-94-8 C₂₂H₁₄N₆O₄ 
• 920899-72-5 C₂₂H₁₆N₆O₄ 
• 920849-64-5 C₃₄H₂₇N₇O₂ 
• 910579-09-8 N-{2-[2-(2-cyano-ethyl)-5-(4-nitro-phenyl)-2H-pyrazol-3-ylamino]-phenyl}-2,2,2-trifluoro-acetamide 
• 327091-68-9 [2-(1H-benzoimidazol-2-yl)-1-(4-nitro-phenyl)-ethylidene]-hydrazine 

Relevant academic research and scientific papers

Selective recyclization of 2-aroylmethyl-1H-benzimidazole hydrazones by condensation with dimethylformamide

2-Aroylmethyl-1H-benzimidazole hydrazones are converted to 1-[pyrazol-3(5)-yl]benzimidazoles by refluxing in dimethylformamide in the presence of trifluoroacetic acid. The same products are obtained by refluxing 2-aroylmethyl-1H-benzimidazoles with hydrazine hydrochloride in dimethylformamide. Electron donor substituents in the para position of the aryl fragment of the starting compounds do not favor the reaction.

Tautomeric equilibria in solutions of 2-phenacylbenzimidazoles

Detailed NMR spectral analysis of DMSO-d6 solutions of the series of substituted 2-phenacylbenzimidazoles (ketimine form, K) reveals two from three tautomeric forms. Integrals of the 1H NMR signals are used in establishing the molar ratio of tautomers. The experimental analyses are supported by quantum-chemical calculations, which satisfactorily reproduced the experimental trends. Although the reported semiempirical quantum-chemical calculations show that enaminone E, i.e., 2-(1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)-1-phenylethan-1-one, was thermodynamically most stable, the results of MP2 ab initio calculations reveal the following order of stability: Ketimine > enolimine > enaminone (substituents do not affect this sequence). 13C CPMAS NMR spectral data reveal that in the crystalline state the enolimine tautomer O is predominant in the p-CH3 and p-NO2 substituted congeners.