methyl-[1-(4-methylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:methyl-[1-(4-methylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester
CAS No.:663179-21-3
Molecular Formula:C₂₃H₂₉N₃O₇
Molecular Weight:459.499
Hs Code.:

methyl-[1-(4-methylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-carbamic acid <i>tert</i>-butyl ester

Synonyms:methyl-[1-(4-methylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

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Chemical Property of methyl-[1-(4-methylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

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Technology Process of methyl-[1-(4-methylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

There total 9 articles about methyl-[1-(4-methylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 624-83-9
methyl isocyanate

: 578729-97-2
N-[1-(4-hydroxyphenyl)-3-(4-nitrophenoxy)propyl]-N-methylcarbamic acid tert-butyl ester

: 663179-21-3
methyl-[1-(4-methylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 663179-21-3
methyl-[1-(4-methylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: PPh₃; diethyl azodicarboxylate / tetrahydrofuran; toluene / 1 h / 20 °C

2: 820 mg / NaOH / methanol; H₂O / 0.5 h / 65 °C

3: 96 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

With sodium hydroxide; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 1: Mitsunobu reaction;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 663179-21-3
methyl-[1-(4-methylcarbamoyloxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: ethanol / 2 h / 90 °C

2: sulfuric acid / 6 h / 80 °C

3: tetrahydrofuran / 12 h / 20 °C

4: K₂CO₃ / dimethylformamide / 3 h / 20 °C

5: LiAlH₄ / tetrahydrofuran / 0.17 h / -20 - -10 °C

6: PPh₃; diethyl azodicarboxylate / tetrahydrofuran; toluene / 1 h / 20 °C

7: 820 mg / NaOH / methanol; H₂O / 0.5 h / 65 °C

8: 96 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; sulfuric acid; potassium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 6: Mitsunobu reaction;