C₂₃H₂₃F₂NO₄

Base Information

• Chemical Name: C₂₃H₂₃F₂NO₄
• CAS No.: 1544022-26-5
• Molecular Formula: C₂₃H₂₃F₂NO₄
• Molecular Weight: 415.437
• Mol file: 1544022-26-5.mol

Synonyms:C₂₃H₂₃F₂NO₄

Chemical Property of C₂₃H₂₃F₂NO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₃F₂NO₄

There total 10 articles about C₂₃H₂₃F₂NO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H16F2O4 + benzyl alcohol (100-51-6,185532-71-2) → C23H23F2NO4 (1544022-32-3) + C23H23F2NO4 (1544022-26-5)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; In toluene; at 80 ℃; Inert atmosphere;

Reference yield:

1,4-dioxa-spiro[4.5]dec-6-en-8-one (4683-24-3) → C23H23F2NO4 (1544022-26-5)

Guidance literature:

Multi-step reaction with 8 steps

1.1: sodium hydride / dimethyl sulfoxide / 0.33 h

1.2: 4 h

2.1: sodium hydride / 80 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C

4.1: sodium carbonate / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

4.2: 12 h / 20 °C / Inert atmosphere

5.1: magnesium / methanol / Reflux; Inert atmosphere

6.1: sodium methylate / methanol / Reflux; Inert atmosphere

7.1: lithium hydroxide monohydrate; water / methanol; tetrahydrofuran / 3 h

8.1: diphenyl phosphoryl azide; triethylamine / toluene / 80 °C / Inert atmosphere

With lithium hydroxide monohydrate; diphenyl phosphoryl azide; water; sodium methylate; sodium hydride; sodium carbonate; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

cyclohexanedione monoethylene ketal (4746-97-8) → C23H23F2NO4 (1544022-26-5)

Guidance literature:

Multi-step reaction with 10 steps

1.1: triethylamine / dichloromethane / 0.42 h / -5 °C

2.1: palladium diacetate / acetonitrile / 20 °C

3.1: sodium hydride / dimethyl sulfoxide / 0.33 h

3.2: 4 h

4.1: sodium hydride / 80 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C

6.1: sodium carbonate / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

6.2: 12 h / 20 °C / Inert atmosphere

7.1: magnesium / methanol / Reflux; Inert atmosphere

8.1: sodium methylate / methanol / Reflux; Inert atmosphere

9.1: lithium hydroxide monohydrate; water / methanol; tetrahydrofuran / 3 h

10.1: diphenyl phosphoryl azide; triethylamine / toluene / 80 °C / Inert atmosphere

With lithium hydroxide monohydrate; diphenyl phosphoryl azide; water; sodium methylate; palladium diacetate; sodium hydride; sodium carbonate; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;

upstream raw materials:

benzyl alcohol

cyclohexanedione monoethylene ketal

1,4-cyclohexanedione-1-ethylene acetal 4-trimethylsilyl enol ether

1,4-dioxa-spiro[4.5]dec-6-en-8-one

Downstream raw materials:

C₂₁H₁₉F₂NO₃

Refernces