(R)-5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3-ethyl-benzoylamino)-5-oxo-pentanoic acid

Base Information

Chemical Name:(R)-5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3-ethyl-benzoylamino)-5-oxo-pentanoic acid
CAS No.:137795-39-2
Molecular Formula:C₂₃H₃₂N₂O₄
Molecular Weight:400.518
Hs Code.:

Synonyms:(R)-5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3-ethyl-benzoylamino)-5-oxo-pentanoic acid

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Chemical Property of (R)-5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3-ethyl-benzoylamino)-5-oxo-pentanoic acid

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Technology Process of (R)-5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3-ethyl-benzoylamino)-5-oxo-pentanoic acid

There total 3 articles about (R)-5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3-ethyl-benzoylamino)-5-oxo-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 176-64-7
8-azaspiro[4.5]decane

: 137795-39-2
(R)-5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3-ethyl-benzoylamino)-5-oxo-pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) triethylamine, ethyl chloroformate / 1.) THF, -10 deg C, 15 min, 2.)a) THF, -10 deg C, 1 h, b) RT, 3 h

2: H₂, H₂O / 10percent Pd/activated charcoal / methanol / 2 h / 760 Torr / Ambient temperature

3: aq. NaOH / tetrahydrofuran / 3 h / Ambient temperature

With sodium hydroxide; water; hydrogen; chloroformic acid ethyl ester; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm00079a003

Reference yield:

: 59486-73-6
(2R)-5-(benzyloxy)-2-{[(benzyloxy)carbonyl]amino}-5-oxopentanoic acid

: 137795-39-2
(R)-5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3-ethyl-benzoylamino)-5-oxo-pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) triethylamine, ethyl chloroformate / 1.) THF, -10 deg C, 15 min, 2.)a) THF, -10 deg C, 1 h, b) RT, 3 h

2: H₂, H₂O / 10percent Pd/activated charcoal / methanol / 2 h / 760 Torr / Ambient temperature

3: aq. NaOH / tetrahydrofuran / 3 h / Ambient temperature

With sodium hydroxide; water; hydrogen; chloroformic acid ethyl ester; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm00079a003

Reference yield:

: 137822-90-3
(R)-5-(8-Aza-spiro[4.5]dec-8-yl)-4-benzyloxycarbonylamino-5-oxo-pentanoic acid benzyl ester

: 137795-39-2
(R)-5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3-ethyl-benzoylamino)-5-oxo-pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: H₂, H₂O / 10percent Pd/activated charcoal / methanol / 2 h / 760 Torr / Ambient temperature

2: aq. NaOH / tetrahydrofuran / 3 h / Ambient temperature

With sodium hydroxide; water; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm00079a003