176-64-7

Basic information

• Product Name: 8-AZASPIRO[4.5]DECANE
• Synonyms: 8-AZASPIRO[4.5]DECANE;8-Azaspiro[4.5]decane hydrochloride salt;8-Aza-Spiro[4.5]Decane(WX100240)
• CAS NO: 176-64-7
• Molecular Formula: C₉H₁₇N
• Molecular Weight: 139.23798
• Mol File: 176-64-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 205.7 °C at 760 mmHg
• Flash Point: 72.7 °C
• Appearance: /
• Density: 0.94 g/cm³
• Vapor Pressure: 0.247mmHg at 25°C
• Refractive Index: 1.496
• CAS DataBase Reference: 8-AZASPIRO[4.5]DECANE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-AZASPIRO[4.5]DECANE(176-64-7)
• EPA Substance Registry System: 8-AZASPIRO[4.5]DECANE(176-64-7)

Safety Data

• Hazardous Substances Data: 176-64-7(Hazardous Substances Data)

Usage

General Description

8-Azaspiro[4.5]decane is a chemical compound belonging to the class of organic compounds known as azaspirodecane derivatives. These are organic compounds featuring a spirodecane moiety that is substited by one or more nitrogen atoms. The systematic name of this chemical is 8-azaspiro[4.5]decane. It's a relatively complex structure which is found in a broad range of application in chemical and medicinal industry. It usually appears as a colourless liquid and has potential uses in organic synthesis and pharmaceuticals applications based on its spiro structure. However, detailed information about its potential hazards, ecotoxicity or biological activities are not thoroughly studied and recorded.

InChI:InChI=1/C9H17N/c1-2-4-9(3-1)5-7-10-8-6-9/h10H,1-8H2

Upstream product

• 1075-89-4 tetramethylene glutarimide 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 291544-98-4 2-(8-Azaspiro[4.5]dec-8-yl)benzophenon 
• 263408-25-9 (E)-2-(8-Azaspiro[4.5]dec-8-yl)benzaldoxim 
• 263408-12-4 2-(8-Azaspiro[4.5]dec-8-yl)benzamid 
• 291544-76-8 α-[2-(8-Azaspiro[4.5]dec-8-yl)phenyl]benzylalkohol 
• 1262396-09-7 (+/-)(7-(((5-chloropyridin-2-yl)amino)methyl)-8-azaspiro[4.5]decan-8-yl)(2-methyl-5-phenylthiazol-4-yl)methanone 
• 1262396-07-5 (+/-)-(2-methyl-5-phenylthiazol-4-yl)(7-(((6-methylpyridin-2-yl)amino)methyl)-8-azaspiro[4.5]decan-8-yl)methanone 
• 958852-76-1 Methyl (S)-2-[(8-azaspiro[4.5]decane-8-carbonyl)amino]-4,4-difluoro-5-phenylpentanoate 
• 870082-40-9 2-(8-azaspiro[4.5]dec-8-yl)-1,6-dihydro-1-methyl-6-oxo-5-(phenylmethoxy)-4-pyrimidinecarboxylic acid ethyl ester 
• 137795-36-9 (R)-5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,4-dichloro-benzoylamino)-5-oxo-pentanoic acid 
• 137795-62-1 (S)-5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,4-dichloro-benzoylamino)-5-oxo-pentanoic acid 
• 137795-35-8 CR 2194 

Relevant articles and documents

Benzoxazinone derivatives and their use as antibacterial agents

The invention discloses benzoxazinone derivatives, a synthesis method and applications thereof. The derivatives can be used as an antibacterial agent for treating infectious diseases caused by bacteria, especially tuberculosis (TB) caused by mycobacterium. Specifically, the invention relates to compounds represented by the formula (I), pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising the provided compounds; wherein the R1 to R4 are defined in the description. The invention aim to prepare novel compounds capable of inhibiting the mycobacterium activity, the compounds can be used as a potential novel drug for treating infectious diseases caused by bacteria, moreover, the compounds can be used to treat or prevent tuberculosis (TB) caused by mycobacterium, at the same time the problems related with drug resistance can be solved, and the drug metabolism property can be improved on the basis that the mycobacterium tuberculosis resistant activity is not influenced.

SPIRO AMINO COMPOUNDS SUITABLE FOR THE TREATMENT OF INTER ALIA SLEEP DISORDERS AND DRUG ADDICTION

The invention concerns a spiro-amino compound of Formula (Vl) wherein m is 1 or 2 or 3, n is 1 or 2, R is selected from a 5- or 6-membered aromatic ring and a 5- or 6-membered heteroaromatic ring comprising 1 to 3 heteroatoms selected from S, O e N, such ring being substituted with one or two substituents selected from the group consisting of (C1-C3)alkyl, halogen, (C3-C5)cycloalkyloxy, (C1-C3)alkylcarbonyl, phenyl optionally substituted with one or more halogen atoms, a 5- or 6-membered heterocycle comprising at least one nitrogen atom; P is a substituent Q or COQ, wherein Q is selected from the group consisting of phenyl, pyridil, pyrimidil, quinolyl, isoquinolyl, quinoxalyl, benzofuranyl, imidazotriazolyl, being such Q optionally substituted with one or more substituents selected from the group consisting of (C1-C3)alkyl, halogen, trifluoromethyl, carbammido, methylcarbammido, carboxy, methylcarboxy or a pharmaceutically acceptable salt thereof.

Cyclic hexapeptides having antibiotic activity

This invention relates to new polypeptide compound represented by general formula (I), wherein R1, R2, R3, R4, R5 and R6 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on β-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.