ethyl 2-butyryl-3-<(4-hydroxy-2-methoxyphenyl)amino>acrylate

Base Information

• Chemical Name: ethyl 2-butyryl-3-<(4-hydroxy-2-methoxyphenyl)amino>acrylate
• CAS No.: 126059-04-9
• Molecular Formula: C₁₆H₂₁NO₅
• Molecular Weight: 307.346
• Mol file: 126059-04-9.mol

Synonyms:ethyl 2-butyryl-3-<(4-hydroxy-2-methoxyphenyl)amino>acrylate

Chemical Property of ethyl 2-butyryl-3-<(4-hydroxy-2-methoxyphenyl)amino>acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-butyryl-3-<(4-hydroxy-2-methoxyphenyl)amino>acrylate

There total 1 articles about ethyl 2-butyryl-3-<(4-hydroxy-2-methoxyphenyl)amino>acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

4-Amino-3-methoxyphenol (61638-01-5) + ethyl 2-(ethoxymethylene)-3-oxohexanoate (125500-84-7) → ethyl 2-butyryl-3-<(4-hydroxy-2-methoxyphenyl)amino>acrylate (126059-04-9)

Guidance literature:

at 100 ℃; for 0.166667h;

DOI:10.1021/jm00014a026

Reference yield: 52.0%

benzoyl chloride (98-88-4) + ethyl 2-butyryl-3-<(4-hydroxy-2-methoxyphenyl)amino>acrylate (126059-04-9) → ethyl 2-butyryl-3-<<4-(benzoyloxy)-2-methoxyphenyl>amino>acrylate (126059-05-0)

Guidance literature:

With pyridine; In dichloromethane; Ambient temperature;

DOI:10.1021/jm00014a026

Reference yield:

ethyl 2-butyryl-3-<(4-hydroxy-2-methoxyphenyl)amino>acrylate (126059-04-9) → 1-(6-Hydroxy-8-methoxy-4-o-tolylamino-quinolin-3-yl)-butan-1-one

Guidance literature:

Multi-step reaction with 5 steps

1: 52 percent / pyridine / CH₂Cl₂ / Ambient temperature

2: 62 percent / diphenyl ether / 0.75 h / Heating

3: POCl₃ / 0.67 h / Heating

4: dioxane / 2 h / Heating

5: 10percent KOH / methanol / 0.17 h / Heating

With pyridine; potassium hydroxide; trichlorophosphate; In 1,4-dioxane; methanol; diphenylether; dichloromethane;

DOI:10.1021/jm00014a026

upstream raw materials:

4-Amino-3-methoxyphenol

ethyl 2-(ethoxymethylene)-3-oxohexanoate

Downstream raw materials:

ethyl 2-butyryl-3-<<4-(benzoyloxy)-2-methoxyphenyl>amino>acrylate

3-butyryl-6-benzoyloxy-8-methoxy-4(1H)-quinolone

3-butyryl-6-benzoyloxy-4-chloro-8-methoxyquinoline